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Lung Proteomics in Intensive Care

  • E. Kipnis
  • K. Hansen

Abstract

The advent of routinely available genomics and sequencing of the human genome, among others, associated with advances in technology previously limited to biochemical research, and in bioinformatics has brought the new field of proteomics within the reach of the life sciences and even clinical research. Important hypotheses are increasingly being generated in lung disease by biomarker identification from screening of clinical samples. However, proteomics, ideally suited for biomarker discovery, is only just emerging as a field of research in intensive care and has, to date, mostly been applied to serumin studies of sepsis [1, 2, 3, 4, 5]. The purpose of this chapter is to overview the rationale, basics, methods, pitfalls, applications, and future directions for lung proteomics in intensive care.

Keywords

Acute Lung Injury Severe Acute Respiratory Syndrome Exhale Breath Condensate Severe Acute Respiratory Syndrome Epithelial Line Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • E. Kipnis
    • 1
  • K. Hansen
    • 2
  1. 1.Department of Surgical Intensive Care Hôpital Huriez Centre Hospitalier RégionalUniversitaire de LilleLilleFrance
  2. 2.Cancer Center Proteomics CoreUniversity of Colorado DenverAuroraUSA

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