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Mitochondrial Genetics and Sepsis

  • A. Pyle
  • P. Chinnery
  • S. Baudouin

Abstract

Mitochondria are intracellular organelles that generate the principal source of cellular energy in the form of adenosine triphosphate (ATP). In a highly efficient process, mitochondria convert both carbohydrate and fat into high-energy phosphate compounds by a series of intermediate steps involving electron transfer. Emerging data implicate mitochondrial damage and dysfunction as critical factors in the pathogenesis of sepsis.

Keywords

Sperm Motility Mitochondrial Biogenesis Mitochondrial Uncouple Protein Oxidative Phosphorylation System Mitochondrial Genetic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • A. Pyle
    • 1
  • P. Chinnery
    • 1
  • S. Baudouin
    • 2
  1. 1.Mitochondrial Research Group Institute of Ageing and HealthNewcastle UniversityNewcastle upon TyneUK
  2. 2.Department of AnesthesiaRoyal Victoria InfirmaryNewcastle upon TyneUK

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