Hydrogen Sulfide: A Metabolic Modulator and a Protective Agent in Animal Models of Reperfusion Injury

  • C. Szabó
  • P. Asfar
  • P. Radermacher


Hydrogen sulfide (H2S), a gas with the characteristic odor of rotten eggs, is known for its toxicity and as an environmental hazard [1, 2, 3, 4, 5]. Recently H2S has been recognized as a signaling molecule of the cardiovascular, inflammatory and nervous systems. Alongside with nitric oxide (NO) and carbon monoxide, it is now referred to as the “third endogenous gaseous transmitter” [6]. Inhalation of gaseous H2S and administration of compounds that donate H2S have been studied in various models of ischemia-reperfusion and circulatory shock [7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24].


Acute Lung Injury Hydrogen Sulfide KATP Channel Hydrogen Sulphide Myocardial Infarct Size 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • C. Szabó
    • 1
  • P. Asfar
    • 2
  • P. Radermacher
    • 3
  1. 1.Department of AnesthesiologyThe University of Texas Medical BranchGalvestonUSA
  2. 2.Department of Intensive Care and Hyperbaric MedicineCentre Hospitalo-UniversitaireAngersFrance
  3. 3.Sektion Anästhesiologische Pathophysiologie und VerfahrensentwicklungUniversitätsklinikumUlmGermany

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