Abstract
Although the role of Toll-like receptor 4 (TLR4) in bacterial infection and sepsis is well characterized, recent studies have also shown that TLR4 can play an important role in contributing to acute inflammatory processes and organ dysfunction in settings in which lipopolysaccharide (LPS) or other bacterial products are not present. In particular, there is increasing evidence that TLR4 is not just a receptor for LPS, but can also transduce other pro-inflammatory signals and, thereby, contribute to cellular activation leading to acute lung injury (ALI) and other organ system dysfunction.
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References
Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82: 47–95
Shenkar R, Abraham E (1999) Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-kappa B, and cyclic AMP response element binding protein. J Immunol 163: 954–962
Shiotani S, Shimada M, Taketomi A, et al (2007) Rho-kinase as a novel gene therapeutic target in treatment of cold ischemia/reperfusion-induced acute lethal liver injury: effect on hepatocellular NADPH oxidase system. Gene Ther 14: 1425–1433
Tan LR, Waxman K, Clark L, et al (1993) Superoxide dismutase and allopurinol improve survival in an animal model of hemorrhagic shock. Am Surg 59: 797–800
Barsness KA, Arcaroli J, Harken AH, et al (2004) Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol 287: R592–599
Oyama J, Blais C Jr, Liu X, et al (2004) Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109: 784–789
Wu H, Chen G, Wyburn KR, et al (2007) TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 117: 2847–2859
Bowler RP, Arcaroli J, Abraham E, Patel M, Chang LY, Crapo JD (2003) Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. Am J Physiol Lung Cell Mol Physiol 284: L680–687
Bowler RP, Arcaroli J, Crapo JD, Ross A, Slot JW, Abraham E (2001) Extracellular superoxide dismutase attenuates lung injury after hemorrhage. Am J Respir Crit Care Med 164: 290–294
Li Q, Bolli R, Qiu Y, et al (2001) Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarction. Circulation 103: 1893–1898
Shenkar R, Abraham E (1997) Hemorrhage induces rapid in vivo activation of CREB and NFkappaB in murine intraparenchymal lung mononuclear cells. Am J Respir Cell Mol Biol 16: 145–152
Lorne E, Zmijewski JW, Zhao X, et al (2008) Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production. Am J Physiol Cell Physiol 294: C985–993
Park HS, Jung HY, Park EY, Kim J, Lee WJ, Bae YS (2004) Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol 173: 3589–3593
Powers KA, Szaszi K, Khadaroo RG, et al (2006) Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages. J Exp Med 203: 1951–1961
Nakahira K, Kim HP, Geng XH, et al (2006) Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med 203: 2377–2389
Letarte PB, Lieberman K, Nagatani K, Haworth RA, Odell GB, Duff TA (1993) Hemin: levels in experimental subarachnoid hematoma and effects on dissociated vascular smooth-muscle cells. J Neurosurg 79: 252–255
Nath KA, Vercellotti GM, Grande JP, et al (2001) Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1. Kidney Int 59: 106–117
Jeney V, Balla J, Yachie A, et al (2002) Pro-oxidant and cytotoxic effects of circulating heme. Blood 100: 879–887
Figueiredo RT, Fernandez PL, Mourao-Sa DS, et al (2007) Characterization of heme as activator of Toll-like receptor 4. J Biol Chem 282: 20221–20229
Imai Y, Kuba K, Neely GG, et al (2008) Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133: 235–249
Agren UM, Tammi RH, Tammi MI (1997) Reactive oxygen species contribute to epidermal hyaluronan catabolism in human skin organ culture. Free Radic Biol Med 23: 996–1001
Termeer C, Benedix F, Sleeman J, et al (2002) Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 195: 99–111
Teder P, Vandivier RW, Jiang D, et al (2002) Resolution of lung inflammation by CD44. Science 296: 155–158
Teriete P, Banerji S, Noble M, et al (2004) Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Mol Cell 13: 483–496
Wang Q, Teder P, Judd NP, Noble PW, Doerschuk CM (2002) CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice. Am J Pathol 161: 2219–2228
Jiang D, Liang J, Fan J, et al (2005) Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 11: 1173–1179
Vaneker M, Joosten LA, Heunks LM, et al (2008) Low-tidal-volume mechanical ventilation induces a toll-like receptor 4-dependent inflammatory response in healthy mice. Anesthesiology 109: 465–472
Ha T, Li Y, Hua F, et al (2005) Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res 68: 224–234
Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418: 191–195
Wang H, Bloom O, Zhang M, et al (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science 285: 248–251
Ulloa L, Batliwalla FM, Andersson U, Gregersen PK, Tracey KJ (2003) High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis. Arthritis Rheum 48: 876–881
Abraham E, Arcaroli J, Carmody A, Wang H, Tracey KJ (2000) HMG-1 as a mediator of acute lung inflammation. J Immunol 165: 2950–2954
Yang H, Ochani M, Li J, et al (2004) Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci USA 101: 296–301
Park JS, Gamboni-Robertson F, He Q, et al (2006) High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol 290: C917–924
Sha Y, Zmijewski J, Xu Z, Abraham E (2008) HMGB1 develops enhanced proinflammatory activity by binding to cytokines. J Immunol 180: 2531–2537
Asea A, Rehli M, Kabingu E, et al (2002) Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277: 15028–15034
Basu S, Binder RJ, Suto R, Anderson KM, Srivastava PK (2000) Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol 12: 1539–1546
Asea A (2007) Mechanisms of HSP72 release. J Biosci 32: 579–584
Osterloh A, Veit A, Gessner A, Fleischer B, Breloer M (2008) Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12. Int Immunol 20: 433–443
Tsan MF, Gao B (2004) Cytokine function of heat shock proteins. Am J Physiol Cell Physiol 286: C739–744
Galloway E, Shin T, Huber N, et al (2008) Activation of hepatocytes by extracellular heat shock protein 72. Am J Physiol Cell Physiol 295: C514–520
Zou N, Ao L, Cleveland JC Jr, et al (2008) Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion. Am J Physiol Heart Circ Physiol 294: H2805–2813
Fernandez-Lizarbe S, Pascual M, Gascon MS, Blanco A, Guerri C (2008) Lipid rafts regulate ethanol-induced activation of TLR4 signaling in murine macrophages. Mol Immunol 45: 2007–2016
Blanco AM, Perez-Arago A, Fernandez-Lizarbe S, Guerri C (2008) Ethanol mimics ligandmediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells. J Neurochem 106: 625–639
Yohe HC, O’Hara KA, Hunt JA, et al (2006) Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 290: G1269–1279
Williams AM, Langley PG, Osei-Hwediah J, Wendon JA, Hughes RD (2003) Hyaluronic acid and endothelial damage due to paracetamol-induced hepatotoxicity. Liver Int 23: 110–115
Michael SL, Mayeux PR, Bucci TJ, et al (2001) Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity. Nitric Oxide 5: 432–441
Hinson JA, Bucci TJ, Irwin LK, Michael SL, Mayeux PR (2002) Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice. Nitric Oxide 6: 160–167
Knight TR, Ho YS, Farhood A, Jaeschke H (2002) Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione. J Pharmacol Exp Ther 303: 468–475
Laukkanen MO, Leppanen P, Turunen P, et al (2001) EC-SOD gene therapy reduces paracetamol-induced liver damage in mice. J Gene Med 3: 321–325
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Lorne, E., Dupont, H., Abraham, E. (2009). Non-septic Acute Lung Injury and Inflammation: Role of TLR4. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92278-2_16
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DOI: https://doi.org/10.1007/978-0-387-92278-2_16
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