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Clarithromycin: A Promising Immunomodulator in Sepsis

  • E. J. Giamarellos-Bourboulis
Conference paper

Abstract

Severe sepsis and septic shock are among the leading causes of death, representing the 10th most common cause of death in the United States of America [1]. The high mortality rates, ranging between 35 and 50 % despite adequate antimicrobial treatment [2], have encouraged intense research efforts to better understand the mechanisms underlying the pathogenesis of sepsis. As a consequence, sepsis syndrome is now recognized as a complex entity created by an intense inflammatory reaction that is generated in the host after stimulation of the innate and adaptive immune systems by bacterial components [3].

Keywords

Cystic Fibrosis Septic Shock Severe Sepsis Antimicrob Agent Pneumococcal Pneumonia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • E. J. Giamarellos-Bourboulis
    • 1
  1. 1.4th Department of Internal MedicineAttikon University HospitalAthensGreece

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