The Effects of Exercise on Appetite Control



In the face of the current obesity epidemic and high prevalence of physical inactivity, it is extremely important to determine how inactivity and exercise (both in the short- and long-term) impact on different aspects of appetite. Exercise has been shown to improve energy compensation by leading to a more sensitive eating behavior in response to previous energy intake (EI). The mechanisms whereby this occurs have yet to be clarified, but exercise has been shown to induce changes in appetite-regulating hormones which may contribute to better appetite control. Acute exercise does not have a significant impact on total ghrelin (TG), independent of its intensity or duration, but increases the release of satiety hormones (polypeptide YY (PYY), glucagon-like peptide-1 (GLP-1), and pancreatic polypeptide (PP)). There is some evidence for suppression of acylated ghrelin (AG) after high-intensity and resistance exercise and this, together with increased release of satiety peptides, is likely to contribute to the phenomenon of “exercise-induced anorexia.” Chronic exercise per se does not increase TG plasma levels; however, a compensatory increase may occur in response to exercise-induced weight loss. There is some evidence to suggest that chronic exercise reduces the AG/DG ratio and increases GLP-1, PYY, and PP plasma levels, therefore creating an appetite-inhibitory state which favors weight loss and prevents weight regain. Finally, exercise seems to have a more favorable impact in men compared with women, in terms of the release of appetite-regulating hormones. In conclusion, exercise seems to have a beneficial impact on appetite by improving energy compensation and leading to changes in appetite-regulating hormones toward appetite suppression. These findings reinforce the key role of exercise in body weight management and energy balance. More research is needed to confirm and elucidate the potential link between changes in appetite-regulating hormones in response to exercise and changes in subjective feelings of hunger/fullness, food intake, and weight loss.


Energy Intake Acute Exercise Pancreatic Polypeptide Negative Energy Balance Chronic Exercise 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Energy balance


Energy intake


Relative energy intake


Energy expenditure




Total ghrelin


Acylated ghrelin


Desacyl ghrelin


Polypeptide YY


Glucagon-like peptide-1


Pancreatic polypeptide


Physical activity


Area under the curve


High-energy preload


Low-energy preload


Maximal oxygen consumption



The first author would like to thank the “Fundação para a Ciência e a Tecnologia” (Portugal) for research funding to develop some of the studies described in this chapter.


  1. Bailey DM, Davies B, Castell LM, Newsholme EA, Calam J. J Appl Physiol. 2001;90:105–13.PubMedGoogle Scholar
  2. Blundell JE. Obesity. 2006;14:160S–3S.PubMedCrossRefGoogle Scholar
  3. Broom D, Batterham RL, King JA, Stensel DJ. Am J Physiol Regul Integr Comp Physiol. 2009;296:29–35.CrossRefGoogle Scholar
  4. Broom DR, Stensel DJ, Bishop NC, Burns SF, Miyashita M. J Appl Physiol. 2007;102:2165–71.PubMedCrossRefGoogle Scholar
  5. Catenacci VA, Ogden LG, Stuht J, Phelan S, Wing RR, Hill JO, Wyatt HR. Obesity. 2008;16:153–61.PubMedCrossRefGoogle Scholar
  6. Chanoine J-P, Mackelvie KJ, Barr SI, Wong ACK, Meneilly GS, Elahi DH. Obesity. 2008;16:202–4.PubMedCrossRefGoogle Scholar
  7. Cheng MH-Y, Bushnell D, Cannon DT, Kern M. Appetite. 2009;52:193–8.PubMedCrossRefGoogle Scholar
  8. Christ ER, Zehnder M, Boesch C, Trepp R, Mullis PE, Diem P, Decombaz J. Eur J Endocrinol. 2006;154:397–403.PubMedCrossRefGoogle Scholar
  9. Considine RV. J Appl Physiol. 1997;83:3–4.PubMedGoogle Scholar
  10. Dall R, Kanaley J, Hansen TK, Moller N, Christiansen JS, Hosoda H, Kangawa K, Jorgensen JO. Eur J Endocrinol. 2002;147:65–70.PubMedCrossRefGoogle Scholar
  11. Donnelly JE, Kirk EP, Jacobsen DJ, Hill JO, Sullivan DK, Johnson SL. Am J Clin Nutr. 2003;78:950–6.PubMedGoogle Scholar
  12. Doucet E, Cameron J. Appl Physiol Nutr Metab. 2007;32:523–32.PubMedCrossRefGoogle Scholar
  13. Erdmann J, Tahbaz R, Lippl F, Wagenpfeil S, Schusdziarra V. Regul Pept. 2007;143:127–35.PubMedCrossRefGoogle Scholar
  14. Foster-Schubert KE, McTiernan A, Frayo RS, Schwartz RS, Rajan KB, Yasui Y, Tworoger SS, Cummings DE. J Clin Endocrinol Metab. 2005;90:820–5.PubMedCrossRefGoogle Scholar
  15. Ghanbari-Niaki A. Clin Biochem. 2006;10:966–70.CrossRefGoogle Scholar
  16. Greenberg GR, Marliss EB, Zinman B. Horm Metab Res. 1986;18:194–6.PubMedCrossRefGoogle Scholar
  17. Hagobian TA, Sharoff CG, Braun B. Metabolism. 2008;57:393–8.PubMedCrossRefGoogle Scholar
  18. Hagobian TA, Sharoff CG, Stephens BR, Wade GN, Silva JE, Chipkin SR, Braun B. Am J Physiol Regul Integr Comp Physiol. 2009;296:R233–42.PubMedCrossRefGoogle Scholar
  19. Hickey MS, Houmard JA, Considine RV, Tyndall GL, Midgette JB, Gavigan KE, Weidner ML, McCammon MR, Israel RG, Caro JF. Am J Physiol. 1997;272:E526–66.Google Scholar
  20. Hilsted J, Galbo H, Sonne B, Schwartz T, Fahrenkrug J, Schaffalitzky de Muckadell OB, Lauritsen KB, Tronier B. Am J Physiol. 1980;239:G136–40.PubMedGoogle Scholar
  21. Hurley RS, Rossetti BM, O’Dorisio TM, Tenison EB, Welch MA, Rice RR. J Sports Med Phys Fitness. 1991;31:52–6.PubMedGoogle Scholar
  22. Jones TE, Basilio JL, Brophy PM, McCammon MR, Hickner RC. Obesity. 2009;17:1189–95.PubMedGoogle Scholar
  23. Jürimäe J, Jürimäe T, Purge P. Exp Biol Med. 2007;232:904–9.Google Scholar
  24. Jürimäe J, Rämson R, Mäestu J, Purge P, Jürimäe T, Arcieiro PJ, Von Duvillard SP. Med Sci Sports Exerc. 2009;41:137–43.CrossRefGoogle Scholar
  25. Karamouzis I, Karamouziz M, Vrabas IS, Christoulas K, Kyriazis N, Giannoulis E, Mandroukas K. Clin Chem Lab Med. 2002;40:132–6.PubMedCrossRefGoogle Scholar
  26. Kim HJ, Lee S, Kim TW, Kim HH, Jeon TY, Yoon YS, Oh SW, Kwak H, Lee JG. Clin Endocrinol (Oxf). 2008;68:416–22.Google Scholar
  27. King NA, Hester J, Gately PJ. Int J Obes. 2007;31:334–9.CrossRefGoogle Scholar
  28. King NA, Hopkins M, Caudwell P, Stubbs RJ, Blundell JE. Int J Obes. 2008;32:177–84.CrossRefGoogle Scholar
  29. Kraemer RR, Chu H, Castracane VD. Exp Biol Med. 2002;227:701–8.Google Scholar
  30. Kraemer RR, Durand RJ, Acevedo EO, Johnson LG, Kraemer GR, Hebert EP, Castracane VD. Exp Biol Med. 2004a;229:240–6.Google Scholar
  31. Kraemer RR, Durand RJ, Hollander DB, Tryniecki JL, Hebert EP, Castracane VD. Endocrine. 2004b;24:93–8.PubMedCrossRefGoogle Scholar
  32. Leidy HJ, Gardner JK, Frye BR, Snook ML, Schuchert MK, Richard EL, Williams NI. J Clin Endocrinol Metab. 2004;89:2659–64.PubMedCrossRefGoogle Scholar
  33. Long SJ, Hart K, Morgan LM. Br J Nutr. 2002;87:517–23.PubMedCrossRefGoogle Scholar
  34. Mackelvie KJ, Meneilly GS, Elahi D, Wong ACK, Barr SI, Chanoine J-P. J Clin Endocrinol Metab. 2007;92:648–54.PubMedCrossRefGoogle Scholar
  35. Malkova D, McLaughlin R, Manthou E, Wallace AM, Nimmo MA. Horm Metab Res. 2008;40:410–5.PubMedCrossRefGoogle Scholar
  36. Martins C, Morgan L, Truby H. Int J Obes. 2008;32:1337–47.CrossRefGoogle Scholar
  37. Martins C, Morgan LM, Bloom SR, Robertson MD. J Endocrinol. 2007a;193:251–8.PubMedCrossRefGoogle Scholar
  38. Martins C, Truby H, Morgan LM. Br J Nutr. 2007b;98:834–42.PubMedGoogle Scholar
  39. Marzullo P, Salvadori A, Brunani A, Verti B, Walker GE, Fanari P, Tovaglieri I, De Medici C, Savia G, Liuzzi A. Clin Endocrinol (Oxf). 2008;69:970–1.CrossRefGoogle Scholar
  40. Mayer J, Roy P, Mitra KP. Am J Clin Nutr. 1956;4:169–75.PubMedGoogle Scholar
  41. Moore MS. Proc Nutr Soc. 2000;59:193–8.PubMedCrossRefGoogle Scholar
  42. Murgatroyd PR, Goldberg GR, Leahy FE, Gilsenan MB, Prentice AM. Int J Obes. 1999;23:1269–75.CrossRefGoogle Scholar
  43. O’Connor AM, Johnston CF, Buchanan KD, Boreham C, Trinick TR, Riddoch CJ. Int J Sports Med. 1995;16:283–7.PubMedCrossRefGoogle Scholar
  44. Ravussin E, Tschop M, Morales S, Bouchard C, Heiman ML. J Clin Endocrinol Metab. 2001;86:4547–51.PubMedCrossRefGoogle Scholar
  45. Reseland JE, Anderssen SA, Solvoll K, Hjermann I, Urdal P, Holme I, Drevon CA. Am J Clin Nutr. 2001;73:240–5.PubMedGoogle Scholar
  46. Sartorio A, Morpurgo S, Cappielo V, Agosti F, Maraki M, Giordani C, Rigamonti A E, Muller EE, Spada A. J Sports Med Phys Fitness. 2008;48:97–101.PubMedGoogle Scholar
  47. Schmidt A, Maier C, Schaller G, Nowothy P, Bayerle-Eder M, Buranyi B, Luger A, Woizt M. Horm Metab Res. 2004;36:174–7.PubMedCrossRefGoogle Scholar
  48. Sliwowski Z, Lorens K, Konturek SJ, Bielanski W, Zoladz JA. J Physiol Pharmacol. 2001;52:53–70.PubMedGoogle Scholar
  49. Soares JB, Leite-Moreira AF. Peptides. 2008;29:1255–70.CrossRefGoogle Scholar
  50. Stubbs RJ, Hughes DA, Johnstone AM, Horgan GW, King N, Blundell JE. Am J Clin Nutr. 2004;79:62–9.PubMedGoogle Scholar
  51. Stubbs RJ, Sepp A, Hughes DA, Johnstone AM, Horgan GW, King N, Blundell J. Eur J Clin Nutr. 2002a;56:129–40.PubMedCrossRefGoogle Scholar
  52. Stubbs RJ, Sepp A, Hughes DA, Johnstone AM, King N, Horgan G, Blundell JE. Int J Obes. 2002b;26:866–9.CrossRefGoogle Scholar
  53. Sullivan SN, Champion MC, Christofides ND, Adrian TE, Bloom SR. Phys Sportsmed. 1984;12:77–82.Google Scholar
  54. Ueda SY, Yoshikawa T, Katsura Y, Usui T, Nakao H, Fujimoto S. J Endocrinol. 2009;201:151–9.PubMedCrossRefGoogle Scholar
  55. van Walleghen EL, Orr JS, Gentile CL, Davy KP, Davy BM. Int J Obes. 2007;31:1277–85.CrossRefGoogle Scholar
  56. Varo JJ, Martinez-Gonzalez MA, De Irala-Estevez J, Kearney J, Gibney M, Martinez JA. Int J Epidemiol. 2003;32:138–46.PubMedCrossRefGoogle Scholar
  57. Vestergaard ET, Dall R, Lange KHW, Kjaer M, Christiansen JS, Jorgensen JOL. J Clin Endocrinol Metab. 2007;92:297–303.PubMedCrossRefGoogle Scholar
  58. World Health Organization. Global strategy on diet, physical activity and health - obesity and overweight; 2003.
  59. World Health Organization. Obesity and overweight - Fact sheet Nº 311; 2006.
  60. Zoladz JA, Konturek SJ, Duda K, Majerczak J, Sliwowski Z, Grandys M, Bielanski W. J Physiol Pharmacol. 2005;56:63–85.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cancer Research and Molecular Medicine, Faculty of MedicineNorwegian University of Science and TechnologyTrondheimNorway

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