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Dynamics of Feeding Behavior: Role of Hypothalamic and Satiety Signals

  • B. S. Zanutto
  • J. E. R. Staddon
Chapter

Abstract

How are rats, people, and many other omnivores able to regulate food intake both within a meal and over days and weeks? We introduce a homeostatic computational theory for eating regulation whose components can be readily interpreted in terms of neuronal circuits. We propose that the long-term set point (over months and years) is located in the hypothalamus and is modulated both by signals for adiposity as well as some signals from the gut, and also by psychological factors such as learning and arousal (emotion). Hypothalamic efferents are inputs to the hindbrain (principally the nucleus tractus solitarius: NTS) providing the set point for short-term eating regulation. Satiety signals (SSs) and delayed gustatory and gastrointestinal aftereffects of eating act via the NTS as neural feedback governing short-term regulation (within a meal or a day). The model hypothesizes that the NTS acts as a comparator in a feedback control system. When the delayed sequelae of eating (SSs) fall below the short-term set point, eating begins, in on–off fashion. The ingestion of food increments the SSs after a delay; the increasing SSs eventually turn eating off. The model forges real links between a functioning feedback mechanism, neuro–hormonal data, and both short-term (meals) and long-term (eating-rate regulation) behavioral data. The model can explain relevant data from behavioral experiments and has implications for diet and nutrition.

Keywords

Arcuate Nucleus Nucleus Tractus Solitarius Meal Size Meal Frequency Meal Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

NTS

Nucleus tractus solitarius

SSs

Satiety signals

CCK

Cholecystokinin

PYY

Peptide YY

Set PointST

Set point for short-term regulation

Set PointLT

Set point for long-term regulation

PVN

Paraventricular nucleus

LHA

Lateral hypothalamic

x(t)

The satiation value

Φ

Satiation value of a specific food

θ

Threshold value equal to Set PointST

SS

Output of a cascaded series of leaky integrators

i

Number of integrator

Vi

State of integrator i

ai

Time parameter of integrator i (0 < a i < 1)

bi

Input weight

PIM

Post-interruption meal

IMI

Intermeal interval

CINT

Cascaded INTegrator

Notes

Acknowledgments

Supported by grants from Agencia Nacional de Promoción Científica y Tecnológica (PICT 2485), University of Buenos Aires (UBACYT I027), CONICET (PIP 5876) and from Duke University.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.IIBM-Universidad de Buenos Aires, and IBYME-CONICETBuenos AiresArgentina

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