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Folate and the Effects of Prenatal Alcohol on the Brain

  • Yajun Xu
  • Jie Zhao
Chapter

Abstract

Both folate deficiency and prenatal alcohol exposure are factors that affect the development of the brain, inducing severe malformation of the brain and/or impairment of brain functioning and behavior. Alcohol consumption during pregnancy can cause a wide array of disorders in the fetal brain, from subtle changes in intelligence to profound mental retardation, which can be manifested as severe damage in learning capabilities or impaired adaptation abilities for their environments. Folic acid supplementation has positive effects on some of the brain dysfunctions that prenatal alcohol exposure can cause, since alcohol consumption decreases the absorption of folate, which is important for DNA and protein synthesis in brain tissues undergoing rapid growth and differentiation. In addition, the protective effects of folic acid and Vitamin B12 together seem better than either vitamin alone. The possible reasons might be that folic acid and Vitamin B12 are metabolically interdependent, therefore additional supplementation with Vitamin B12 may enhance the utilization and biologic effects of folic acid. However, it is notable that the simplest and most effective way to prevent brain malformation and disorders related to fetal alcohol exposure is to be far away from alcohol during pregnancy. Luckily, folate exists widely in foods, both plant and animal. It is abundant in green leafy vegetables, and liver and liver products also contain high amounts of folate, as does baker’s yeast.

Keywords

Neural Tube Defect Alcohol Exposure Folic Acid Supplementation Folate Deficiency Fetal Alcohol Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

BDNF

Brain-derived neurotrophic factor

BRFSS

Behavioral Risk Factor Surveillance System

CNS

Central nervous system

DNA

Deoxyribonucleic acid

dUMP

Deoxidized uridine monophosphate

dTMP

Deoxidized thymidine monophosphate

FAD

Flavine adenine dinucleotide

MS

Methionine synthetase

MTHF

Methyltetrahydrofolate

MTHFR

Methylenetetrahydrofolate reductase

RBC

Red blood cell

RNI

Recommended nutrient intake

RNA

Ribonucleic acid

SAH

S-adenosyl homocysteine

SAM

S-adenosyl methionine

THF

Tetrahydrofolate

TS

Thymidylate synthetase

UNG

Uracil DNA glycosylase

VB12

Vitamin B12

Notes

Acknowledgment

This work was supported by the Natural Science Foundation of Beijing (No. 7092060).

References

  1. Abate P, Pueta M, Spear NE, Molina JC. Exp Biol Med (Maywood). 2008;233:139–54.CrossRefGoogle Scholar
  2. Bailey LB, Rampersaud GC, Kauwell GP. J Nutr. 2003;133:1961S–8S.PubMedGoogle Scholar
  3. Balk E, Chung M, Raman G, Tatsioni A, Chew P, Ip S, DeVine D, Lau J. Evid Rep Technol Assess. 2006;134:1–161.Google Scholar
  4. Black MM. Food Nutr Bull. 2008;29(2 Suppl):S126–31.PubMedGoogle Scholar
  5. Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2004;53:1178–81.PubMedGoogle Scholar
  6. Cogswell ME, Weisberg P, Spong C. J Nutr. 2003;133 (5 Suppl. 2):1722S–31S.PubMedGoogle Scholar
  7. Cornel MC, de Smit DJ, de Jong van den Berg LT. Reprod Toxicol. 2005;20:411–5.PubMedCrossRefGoogle Scholar
  8. Coppen A, Bolander-Gouaille C. J Psychopharmacol. 2005;19:59–65.PubMedCrossRefGoogle Scholar
  9. Czeizel AE, Dudas I. N Engl J Med. 1992;327:1832–5.PubMedCrossRefGoogle Scholar
  10. D’Anci KE, Rosenberg IH. Curr Opin Clin Nutr Metab Care. 2004;7:659–64.PubMedCrossRefGoogle Scholar
  11. Das UN. Nutrition. 2003;19:686–92.PubMedCrossRefGoogle Scholar
  12. Das UN. Prostaglandins Leukot Essent Fatty Acids. 2008;78:11–19.PubMedCrossRefGoogle Scholar
  13. De Marco P, Merello E, Mascelli S, Capra V. Neurogenetics. 2006;7:201–21.PubMedCrossRefGoogle Scholar
  14. Eichholzer M, Tönz O, Zimmermann R. Lancet. 2006;367:1352–61.PubMedCrossRefGoogle Scholar
  15. Ellinson M, Thomas J, Patterson A. J Hum Nutr Diet. 2004;17:3713–83.CrossRefGoogle Scholar
  16. Food and Drug Administration. Federal Register. 1996;61:8781–97.Google Scholar
  17. Green JH. J Sch Health. 2007;77:103–8.PubMedCrossRefGoogle Scholar
  18. Guerri C, Bazinet A, Riley EP. Alcohol Alcohol. 2009;44:108–14.PubMedGoogle Scholar
  19. Gujska E, Majewska K. Plant Foods Hum Nutr. 2005;60:37–42.PubMedCrossRefGoogle Scholar
  20. Halsted CH, Villanueva JA, Devlin AM, Chandler CJ. J Nutr. 2002;132 (8 Suppl.):2367S–72S.PubMedGoogle Scholar
  21. Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong L. JAMA. 2001;285:2981–6.PubMedCrossRefGoogle Scholar
  22. Johnson MA. Nutr Rev. 2007;65:451–8.PubMedCrossRefGoogle Scholar
  23. Kang SS, Wong PW, Susmano A, Sora J, Norusis M, Ruggie N. Am J Hum Genet. 1991;48:536–45.PubMedGoogle Scholar
  24. Kariluoto S, Vahteristo L, Salovaara H, Katina K, Liukkonen KH, Piironen V. Cereal Chem. 2004;81:134–9.CrossRefGoogle Scholar
  25. Kim YI. Nutr Rev. 2007;65:504–11.PubMedCrossRefGoogle Scholar
  26. Kronenberg G, Harms C, Sobol RW, Cardozo-Pelaez F, Linhart H, Winter B, Balkaya M, Gertz K, Gay SB, Cox D, Eckart S, Ahmadi M, Juckel G, Kempermann G, Hellweg R, Sohr R, Hörtnagl H, Wilson SH, Jaenisch R, Endres M. J Neurosci. 2008;28:7219–30.PubMedCrossRefGoogle Scholar
  27. Matté C, Mackedanz V, Stefanello FM, Scherer EB, Andreazza AC, Zanotto C, Moro AM, Garcia SC, Goncalves CA, Erdtmann B, Salvador M, Wyse AT. Neurochem Int. 2009;54:7–13.PubMedCrossRefGoogle Scholar
  28. Mattson MP, Kruman II, Duan W. Ageing Res Rev. 2002;1:95–111.PubMedCrossRefGoogle Scholar
  29. Mischoulon D, Raab MF. J Clin Psychiatry. 2007;10:28–33.Google Scholar
  30. Morris MS. Nutr Clin Care. 2002;5:124–32.PubMedCrossRefGoogle Scholar
  31. Muldoon RT, McMartin KE. Ethanol Clin Exp Res. 1994;18:333–9.CrossRefGoogle Scholar
  32. Niccols A. Brain Cogn. 2007;65:135–42.PubMedCrossRefGoogle Scholar
  33. Osseyi EO, Wehling RL, Albrecht JA. Cereal Chem. 2001;78:375–8.CrossRefGoogle Scholar
  34. Paul RT, McDonnell AP, Kelly CB. Hum Psychopharmacol. 2004;19:477–88.PubMedCrossRefGoogle Scholar
  35. Picker JD, Coyle JT. Harv Rev Psychiatry. 2005;13:197–205.PubMedCrossRefGoogle Scholar
  36. Schneider JA, Rees DC, Liu Y-T, Clegg JB. Am J Hum Genet. 1998;62:1258–60.PubMedCrossRefGoogle Scholar
  37. Sharpe TT, Alexander M, Hutcherson J, Floyd RL, Brimacombe M, Levine R, Mengel M, Stuber M. J Women Health (Larchmt). 2004;13:133–9.CrossRefGoogle Scholar
  38. Suh JR, Herbig AK, Stover PJ. Annu Rev Nutr. 2001;21:255–82.PubMedCrossRefGoogle Scholar
  39. Sun Y, Strandberg-Larsen K, Vestergaard M, Christensen J, Nybo Andersen AM, Gronbaek M, Olsen J. Am J Epidemiol. 2009;169:313–22.PubMedCrossRefGoogle Scholar
  40. Tough S, Tofflemire K, Clarke M, Newburn-Cook C. Clin Med Res. 2006;4:97–105.PubMedCrossRefGoogle Scholar
  41. Wang LL, Zhang Z, Li Q, Yang R, Pei X, Xu Y, Wang J, Zhou SF, Li Y. Hum Reprod. 2009;24:562–79.PubMedCrossRefGoogle Scholar
  42. Weir DG, McGing PG, Scott JM. Biochem Pharmacol. 1985;34:1–7.PubMedCrossRefGoogle Scholar
  43. Wright AJA, Finglas PM, Southon S. Trends Food Sci. 2001;12:313–21.CrossRefGoogle Scholar
  44. Xu Y, Liu P, Li Y. Wei Sheng Yan Jiu. 2005a;34:61–3.PubMedGoogle Scholar
  45. Xu Y, Zhang G, Li Y. Beijing Da Xue Xue Bao. 2005b;37:346–50.PubMedGoogle Scholar
  46. Xu Y, Li L, Zhang Z, Li Y. Toxicol Lett. 2006a;167:167–72.PubMedCrossRefGoogle Scholar
  47. Xu Y, Li Y, Tang Y, Wang J, Shen X, Long Z, Zheng X. Reprod Toxicol. 2006b;22:56–61.PubMedCrossRefGoogle Scholar
  48. Xu Y, Tang Y, Li Y. Brit J Nutr. 2008;99:455–61.PubMedCrossRefGoogle Scholar
  49. Zintzaras E. J Hum Genet. 2007;52:943–53.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Nutrition and Food Hygiene, School of Public HealthPeking University Health Science CenterBeijingChina

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