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Iodine and Brain Development

  • Pere Berbel
  • Gabriella Morreale de Escobar
Chapter

Abstract

Iodine is an essential component of thyroid hormones thyroxine (T4) and triiodothyronine (T3) that play a fundamental role in brain development and maturation. During gestation, the maternal thyroid has to increase the synthesis of thyroid hormones since the mother is the principal source of T4 and iodine for the fetus and of iodine during lactation. This doubles the needs of maternal iodine intake to 250–300 µg per day. After starvation, iodine deficiency remains the most frequent cause worldwide of preventable mental retardation in children. Severe iodine deficiency results in wide spectrum of disorders including cretinism. Mild iodine deficiency causes maternal hypothyroxinemia, which affects pregnant women even in apparently iodine-sufficient areas. Maternal hypothyroxinemia often goes unnoticed because T3 levels remain within the normal range and thyrotropin (TSH) is not increased. Recent epidemiological data have found that mild maternal hypothyroxinemia during the first month of pregnancy increases the risk of neurodevelopmental abnormalities in children. Experimental data in animal models have shown altered brain cortical cytoarchitecture in pups born to hypothyroxinemic dams. To prevent iodine deficiency during gestation and lactation, the World Health Organization (WHO) recommends a supplement of 250 µg iodine per day for every expectant woman, in addition to the use of iodized salt in households and a diet comprising iodine rich foods. The importance of iodine supplementation to ensure adequately elevated T4 levels in all women considering conception and during pregnancy and lactation is discussed and fully recommended.

Keywords

Thyroid Hormone Iodine Deficiency Iodine Intake Urinary Iodine Iodine Deficiency Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

T2

3,5-Diiodo-L-thyronine or diiodothyronine

T3

3′,3,5-Triiodo-L-thyronine or triiodothyronine

T4

3′,5′,3,5-Tetraiodo-L-thyronine or thyroxine

rT3

3′,5′,3-Triiodo-L-thyronine or reverse-T3

BrdU

5-Bromo-2′-deoxyuridine

5-HTT

5-HT transporter

DAG

Diacyl glycerol

DiI

1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate

DIT

Diiodotyrosine

E

Embryonic day

GABA

Gamma-aminobutyric acid

HAS

Human serum albumin

IP3

Inositol triphosphate

ICCIDD

International Council for the Control of Iodine Deficiency Disorders

D

Iodothyronine deiodinase

LID

Low-iodine diet

MMI

Methimazole

MAP

Mitogen-associated protein

MCT

Monocarboxylate transporter

MIT

Monoiodotyrosine

NHANES

National Health and Nutrition Examination Surveys

OATP

Organic anion transporting polypeptide

PLC

Phospholipase C

P

Postnatal day

PTU

Propylthiouracil

PKC

Protein kinase C

5-HT

Serotonin

TR

T3 receptor

TBG

Thyroid-binding globulin

TSH

Thyrotropin

TTR

Transthyretin

UI

Urinary iodine

WHO

World Health Organization

Notes

Acknowledgments

Supported by a Spanish MICINN Grant: PN I+D+I SAF2009-10689. We thank Prof. J. Bernal for helpful comments.

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Authors and Affiliations

  1. 1.Instituto de NeurocienciasUniversidad Miguel Hernández and Consejo Superior de Investigaciones CientíficasSant Joan d’AlacantSpain

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