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Perinatal Undernutrition and Brain-Derived Neurotrophic Factor

  • Didier Vieau
  • Sylvain Mayeur
  • Marie-Amélie Lukaszewski
  • Fabien Delahave
  • Isabelle Dutriez-Casteloot
  • Christine Laborie
  • Sylvie Deloof
  • Jean Lesage
  • Christophe Breton
Chapter

Abstract

There is now compelling evidence, coming both from animal and human studies, that perinatal alterations such as maternal undernutrition may result in developmental adaptations that permanently change the morphology, physiology, and metabolism in offspring, thereby predisposing individuals to several chronic diseases in adult life. This has led to the notion that some cognitive (depression), psychiatric (schizophrenia), neurodegenerative (Alzheimer disease), and metabolic (hypertension, type 2 diabetes, and obesity) illnesses could be “programmed” during early development. Among the molecules putatively involved in the so-called “Developmental Origin of Health and Adult Diseases,” brain-derived neurotrophic factor is a likely candidate since it plays crucial roles during central nervous system maturation and development. Interestingly, a data have increasingly shown that brain-derived neurotrophic factor exerts an important role in the regulation of energy homeostasis. Indeed, brain-derived neurotrophic factor system alterations are associated with metabolic dysfunctions such as obesity and hyperphagia. We have shown recently that maternal perinatal undernutrition modified both brain-derived neurotrophic factor content and cell proliferation in the central nervous system of the male rat neonate. In view of these data, this chapter selectively focuses on the most recent findings supporting the idea that the brain-derived neurotrophic factor shares the dual role of regulating both energy homeostasis and neural plasticity. It could thus be implicated in the altered perinatal growth and in the increased prevalence of adult diseases frequently observed in offspring of undernourished mothers.

Keywords

Anorexia Nervosa Bulimia Nervosa BDNF Level Adult Disease Central Nervous System Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AD

Alzheimer Disease

AN

Anorexia Nervosa

BDNF

Brain-Derived Neurotrophic Factor

BN

Bulimia Nervosa

BrdU

Bromodeoxyuridine

CNS

Central Nervous System

DMH

Dorsomedial Hypothalamus

DOHAD

Developmental Origin of Health and Adult Diseases

E

Embryonic Day

FR50

50% Food Restriction

HD

Huntington Disease

HPA

Hypothalamo-Pituitary-Adrenal

kDa

Kilodalton

MPU

Maternal Perinatal Undernutrition

P

Postnatal Day

PC

Proprotein Convertase

PNS

Peripheral Nervous System

POMC

Proopiomelanocortin

P75NTR

p75 Neurotrophin Receptor

SAS

Sympatho-Adrenal-System

TrkB

Tyrosine Kinase Receptor B

VMH

Ventromedial Hypothalamus

Notes

Acknowledgments

We are grateful to V. Montel, A. Dickes-Coopman and F. Lefevre for technical assistance. This study was supported by the Conseil Régional du Nord-Pas-de-Calais.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Didier Vieau
    • 1
  • Sylvain Mayeur
  • Marie-Amélie Lukaszewski
  • Fabien Delahave
  • Isabelle Dutriez-Casteloot
  • Christine Laborie
  • Sylvie Deloof
  • Jean Lesage
  • Christophe Breton
  1. 1.Environment Périnatal et Croissance (EA4489), Equipe Dénutritions Maternelles PérinatalesUniversité des Sciences et Technologies de LilleVilleneuve d’AscqFrance

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