The Role of Cholecystokinin (CCK) in Eating Behavior



Cholecystokinin (CCK) is released from the basolateral membrane of the enteroendocrine I cell in response to the presence of nutrients, particularly fatty acids and proteins, in the intestinal lumen. Several forms of CCK are cleaved from the precursor form, with CCK-8 and CCK-58 being the most potent in suppression of food intake. Postprandial CCK stimulates pancreatic secretion, bile release, gallbladder contraction, slowing of gastric emptying and inhibition of food intake, thus controlling the passage of ingesta. Both systemic as well as brain CCK inhibit food intake. Most of CCK’s actions, including control of food intake, are mediated through CCK-1Rs acting through a paracrine mode of action on vagal afferent neurons that innervate the gastrointestinal (GI) tract and terminate in the hindbrain. Changes in dietary environment results in altered behavioral and neuronal responses to CCK. Finally, CCK interacts with several anorexigenic and orexigenic signals as well as adiposity signals to enhance their effects on meal size or energy regulation. This chapter summarizes the role of CCK as a satiation signal, its mechanisms of action, and its potential participation in the regulation of body weight.


Nucleus Tractus Solitarius Increase Food Intake Decrease Food Intake Pancreatic Acinus Vagal Afferents 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Area postrema




Cholecystokinin 1 receptor


Cholecystokinin 2 receptor


Cholecystokinin octapeptide


Diet-induced obesity


Diet-induced obesity resistant


Dorsal vagal complex


Fos-like immunoreactivity










Long-Evans Tokushima Otuska




messenger RNA


Nucleus tractus solitarius


Otsuka Long-Evans Tokushima Fatty


  1. Arya R, Duggirala R, et al. Am J Hum Genet. 2004;74(2):272–82.PubMedGoogle Scholar
  2. Asarian L. Am J Physiol Regul Integr Comp Physiol. 2009;296(1):R51–6.PubMedGoogle Scholar
  3. Asarian L, Geary N. Peptides. 1999;20(4):445–50.PubMedGoogle Scholar
  4. Ballinger AB, Clark ML. Metabolism. 1994;43(6):735–8.PubMedGoogle Scholar
  5. Baptista V, Browning KN, et al. Am J Physiol Regul Integr Comp Physiol. 2007;292(3):R1092–100.PubMedGoogle Scholar
  6. Baranowska B, Radzikowska M, et al. Diabetes Obes Metab. 2000;2(2):99–103.PubMedGoogle Scholar
  7. Blevins JE, Stanley BG, et al. Brain Res. 2000;860(1–2):1–10.PubMedGoogle Scholar
  8. Blevins JE, Overduin J, et al. Brain Res. 2009;1255:98–112.PubMedGoogle Scholar
  9. Boyd KA, óDonovan DG, et al. Am J Physiol Gastrointest Liver Physiol. 2003;284(2):G188–96.PubMedGoogle Scholar
  10. Brenner L, Ritter RC. Appetite. 1995;24(1):1–9.PubMedGoogle Scholar
  11. Brenner LA, Ritter RC. Pharmacol Biochem Behav. 1996;54(3):625–31.PubMedGoogle Scholar
  12. Brenner L, Yox DP, et al. Am J Physiol. 1993;264(5 Pt 2):R972–6.PubMedGoogle Scholar
  13. Broberger C, Holmberg K, et al. Brain Res. 2001;903(1–2):128–40.PubMedGoogle Scholar
  14. Burton-Freeman B, Gietzen DW, et al. Am J Physiol. 1999;276(2 Pt 2):R429–34.PubMedGoogle Scholar
  15. Canova A, Geary N. Appetite. 1991;17(3):221–7.PubMedGoogle Scholar
  16. Chowdhury P, Nishikawa M, et al. Proc Soc Exp Biol Med. 2000;223(3):310–5.PubMedGoogle Scholar
  17. Corp ES, Curcio M, et al. Physiol Behav. 1997;61(6):823–7.PubMedGoogle Scholar
  18. Covasa M, Ritter RC. Peptides. 1998;19(8):1407–15.PubMedGoogle Scholar
  19. Covasa M, Ritter RC. Peptides. 2001;22(8):1339–48.PubMedGoogle Scholar
  20. Covasa M, Grahn J, et al. Auton Neurosci. 2000;84(1–2):8–18.PubMedGoogle Scholar
  21. Covasa M, Marcuson JK, et al. Am J Physiol Regul Integr Comp Physiol. 2001;280(2):R331–7.PubMedGoogle Scholar
  22. Cox JE, Perdue GS, et al. Am J Physiol. 1995;268(1 Pt 2):R150–5.PubMedGoogle Scholar
  23. Date Y, Murakami N, et al. Gastroenterology. 2002;123(4):1120–8.PubMedGoogle Scholar
  24. De Jonghe BC, Hajnal A, et al. Am J Physiol Gastrointest Liver Physiol. 2006;291(4):G640–9.PubMedGoogle Scholar
  25. de Krom M, van der Schouw YT, et al. Diabetes. 2007;56(1):276–80.PubMedGoogle Scholar
  26. de Weerth A, Pisegna JR, et al. Biochem Biophys Res Commun. 1993;194(2):811–8.PubMedGoogle Scholar
  27. Della-Fera MA, Baile CA, et al. Science. 1981;212(4495):687–9.PubMedGoogle Scholar
  28. Dorre D, Smith GP. Physiol Behav. 1998;65(1):11–4.PubMedGoogle Scholar
  29. Eastwood C, Maubach K, et al. Neurosci Lett. 1998;254(3):145–8.PubMedGoogle Scholar
  30. Emond M, Schwartz GJ, et al. Am J Physiol. 1999;276(5 Pt 2):R1545–9.PubMedGoogle Scholar
  31. Feinle C, D’Amato M, et al. Gastroenterology. 1996;110(5):1379–85.PubMedGoogle Scholar
  32. Figlewicz DP, Sipols AJ, et al. Behav Neurosci. 1995;109(3):567–9.PubMedGoogle Scholar
  33. French SJ, Murray B, et al. Int J Obes Relat Metab Disord. 1993;17(5):295–300.PubMedGoogle Scholar
  34. Funakoshi A, Miyasaka K, et al. Biochem Biophys Res Commun. 1994;199(2):482–8.PubMedGoogle Scholar
  35. Gibbs J, Young RC, et al. J Comp Physiol Psychol. 1973;84(3):488–95.PubMedGoogle Scholar
  36. Gidez LI. J Lipid Res. 1973;14(2):169–77.PubMedGoogle Scholar
  37. Glatzle J, Wang Y, et al. J Physiol. 2003;550(Pt 2):657–64.PubMedGoogle Scholar
  38. Glatzle J, Raybould HE, et al. Nutr Neurosci. 2008;11(2):69–74.PubMedGoogle Scholar
  39. Hayes MR, Covasa M. Peptides. 2005;26(11):2322–30.PubMedGoogle Scholar
  40. Hayes MR, Covasa M. Brain Res. 2006a;1103(1):99–107.PubMedGoogle Scholar
  41. Hayes MR, Covasa M. Brain Res. 2006b;1088(1):120–30.PubMedGoogle Scholar
  42. Hayes MR, Moore RL, et al. Am J Physiol Regul Integr Comp Physiol. 2004a;287(4):R817–23.PubMedGoogle Scholar
  43. Hayes MR, Savastano DM, et al. Physiol Behav. 2004b;82(4):663–9.PubMedGoogle Scholar
  44. Helm KA, Rada P, et al. Brain Res. 2003;963(1–2):290–7.PubMedGoogle Scholar
  45. Hill DR, Woodruff GN. Brain Res. 1990;526(2):276–83.PubMedGoogle Scholar
  46. Hokfelt T, Blacker D, et al. Pharmacol Toxicol. 2002;91(6):382–6.PubMedGoogle Scholar
  47. Jorpes E, Mutt V. Nord Med. 1956;56(42):1511–7.PubMedGoogle Scholar
  48. Kawano K, Hirashima T, et al. Diabetes. 1992;41(11):1422–8.PubMedGoogle Scholar
  49. Kopin AS, Lee YM, et al. Proc Natl Acad Sci USA. 1992;89(8):3605–9.PubMedGoogle Scholar
  50. Liddle RA. Annu Rev Physiol. 1997;59:221–42.PubMedGoogle Scholar
  51. Liddle RA, Green GM, et al. Am J Physiol. 1986;251(2 Pt 1):G243–8.PubMedGoogle Scholar
  52. Lieverse RJ, Jansen JB, et al. Int J Obes Relat Metab Disord. 1994;18(8):579–83.PubMedGoogle Scholar
  53. Little TJ, Horowitz M, et al. Obes Rev. 2005;6(4):297–306.PubMedGoogle Scholar
  54. Lo CM, Zhang DM, et al. Am J Physiol Regul Integr Comp Physiol. 2007;293(4):R1490–4.PubMedGoogle Scholar
  55. Malendowicz LK, Spinazzi R, et al. Int J Mol Med. 2003;12(6):903–9.PubMedGoogle Scholar
  56. Matson CA, Ritter RC. Am J Physiol. 1999;276(4 Pt 2):R1038–45.PubMedGoogle Scholar
  57. Matson CA, Reid DF, et al. Am J Physiol Regul Integr Comp Physiol. 2002;282(5):R1368–73.PubMedGoogle Scholar
  58. McLaughlin CL, Baile CA. Pharmacol Biochem Behav. 1979;10(1):87–93.PubMedGoogle Scholar
  59. Melville LD, Smith GP, et al. Pharmacol Biochem Behav. 1992;43(3):975–7.PubMedGoogle Scholar
  60. Moran TH. Physiol Behav. 2008;94(1):71–8.PubMedGoogle Scholar
  61. Moran TH, Bi S. Philos Trans R Soc Lond B Biol Sci. 2006;361(1471):1211–8.PubMedGoogle Scholar
  62. Moran TH, McHugh PR. Am J Physiol. 1982;242(5):R491–7.PubMedGoogle Scholar
  63. Moran TH, Norgren R, et al. Brain Res. 1990;526(1):95–102.PubMedGoogle Scholar
  64. Moran TH, Ameglio PJ, et al. Am J Physiol. 1992;262(1 Pt 2):R46–50.PubMedGoogle Scholar
  65. Moran TH, Field DG, et al. Peptides. 1997;18(4):547–50.PubMedGoogle Scholar
  66. Moran TH, Katz LF, et al. Am J Physiol. 1998;274(3 Pt 2):R618–25.PubMedGoogle Scholar
  67. Nefti W, Chaumontet C, et al. Am J Physiol Regul Integr Comp Physiol. 2009;296(6):R1681–6.PubMedGoogle Scholar
  68. Niederau C, Meereis-Schwanke K, et al. Regul Pept. 1997;70(2–3):97–104.PubMedGoogle Scholar
  69. Ohlsson B, Borg K, et al. Scand J Gastroenterol. 2000;35(6):612–8.PubMedGoogle Scholar
  70. Otsuki M, Williams JA. Am J Physiol. 1983;244(6):G683–8.PubMedGoogle Scholar
  71. Otsuki M, Akiyama T, et al. Am J Physiol. 1995;268(3 Pt 1):E531–6.PubMedGoogle Scholar
  72. Pandya PK, Huang SC, et al. Biochim Biophys Acta. 1994;1224(1):117–26.PubMedGoogle Scholar
  73. Parker BA, Doran S, et al. Clin Endocrinol (Oxf). 2005;62(5):539–46.Google Scholar
  74. Paulino G, Barbier de la Serre C, et al. Am J Physiol Endocrinol Metab. 2009;296(4):E898–903.PubMedGoogle Scholar
  75. Plagemann A, Rake A, et al. Neurosci Lett. 1998;258(1):13–6.PubMedGoogle Scholar
  76. Rao RV, Hadac EM, et al. J Neurochem. 1997;68(6):2356–62.PubMedGoogle Scholar
  77. Raybould HE, Lloyd KC. Ann NY Acad Sci. 1994;713:143–56.PubMedGoogle Scholar
  78. Reeve Jr JR, Green GM, et al. Am J Physiol Gastrointest Liver Physiol. 2003;285(2):G255–65.PubMedGoogle Scholar
  79. Reidelberger RD. Am J Physiol. 1992;263(6 Pt 2):R1354–8.PubMedGoogle Scholar
  80. Reidelberger RD, Hernandez J, et al. Am J Physiol Regul Integr Comp Physiol. 2004;286(6):R1005–12.PubMedGoogle Scholar
  81. Ritter RC. Physiol Behav. 2004a;81(2):249–73.PubMedGoogle Scholar
  82. Ritter RC. Am J Physiol Regul Integr Comp Physiol. 2004b;286(6):R991–3.PubMedGoogle Scholar
  83. Ritter RC, Ritter S, et al. Am J Physiol. 1989;257(5 Pt 2):R1162–8.PubMedGoogle Scholar
  84. Ritter RC, Covasa M, et al. Neuropeptides. 1999;33(5):387–99.PubMedGoogle Scholar
  85. Roses AD. Nat Rev Genet. 2004;5(9):645–56.PubMedGoogle Scholar
  86. Schick RR, Yaksh TL, et al. Am J Physiol. 1989;256(1 Pt 2):R248–54.PubMedGoogle Scholar
  87. Shoji E, Okumura T, et al. Dig Dis Sci. 1997;42(5):915–9.PubMedGoogle Scholar
  88. Simasko SM, Wiens J, et al. Am J Physiol Regul Integr Comp Physiol. 2002;283(6):R1303–13.PubMedGoogle Scholar
  89. Smith GP, Jerome C, et al. Science. 1981;213(4511):1036–7.PubMedGoogle Scholar
  90. South EH, Ritter RC. Peptides. 1988;9(3):601–12.PubMedGoogle Scholar
  91. Sturm K, MacIntosh CG, et al. J Clin Endocrinol Metab. 2003;88(8):3747–55.PubMedGoogle Scholar
  92. Talkad VD, Patto RJ, et al. Biochim Biophys Acta. 1994;1224(1):103–16.PubMedGoogle Scholar
  93. Torregrossa AM, Smith GP. Physiol Behav. 2003;78(1):19–25.PubMedGoogle Scholar
  94. van de Wall EH, Duffy P, et al. Am J Physiol Regul Integr Comp Physiol. 2005;289(3):R695–703.PubMedGoogle Scholar
  95. Voits M, Forster S, et al. Naunyn Schmiedebergs Arch Pharmacol. 1996;354(3):374–8.PubMedGoogle Scholar
  96. Wang L, Martinez V, et al. Brain Res. 1998;791(1–2):157–66.PubMedGoogle Scholar
  97. Wang L, Barachina MD, et al. Regul Pept. 2000;92(1–3):79–85.PubMedGoogle Scholar
  98. Wang C, Zhou DF, et al. World J Gastroenterol. 2007;13(36):4873–80.PubMedGoogle Scholar
  99. Wank SA, Pisegna JR, et al. Ann NY Acad Sci. 1994;713:49–66.PubMedGoogle Scholar
  100. Weatherford SC, Laughton WB, et al. Am J Physiol. 1993;264(2 Pt 2):R244–9.PubMedGoogle Scholar
  101. Weller A, Corp ES, et al. Peptides. 1992;13(5):939–41.PubMedGoogle Scholar
  102. Woltman T, Reidelberger R. Am J Physiol. 1999;276(6 Pt 2):R1701–9.PubMedGoogle Scholar
  103. Woltman T, Castellanos D, et al. Am J Physiol. 1995;269(6 Pt 2):R1420–33.PubMedGoogle Scholar
  104. Yox DP, Ritter RC. Am J Physiol. 1988;255(4 Pt 2):R569–74.PubMedGoogle Scholar
  105. Yox DP, Brenner L, et al. Am J Physiol. 1992;262(4 Pt 2):R554–61.PubMedGoogle Scholar
  106. Zwirska-Korczala K, Konturek SJ, et al. J Physiol Pharmacol. 2007;58 Suppl 1:13–35.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.INRAÉcologie et Physiologie du Système DigestifJouy-en-JosasFrance

Personalised recommendations