Dietary n-3-Polyunsaturated Fatty Acid Deprivation and Cytokine Signaling Pathways in the Brain

Laye, Sophie; Labrousse, Virginie F.; De Smedt-Peyrusse, Veronique

doi:10.1007/978-0-387-92271-3_115

Dietary n-3-Polyunsaturated Fatty Acid Deprivation and Cytokine Signaling Pathways in the Brain

Sophie Laye⁴,
Virginie F. Labrousse &
Veronique De Smedt-Peyrusse

Chapter
First Online: 01 January 2011

192 Accesses

Abstract

The innate immune system of the brain is principally composed of microglial cells and astrocytes, which, once activated, protect neurons against insults (infectious agents, lesions, etc.). Activated glial cells produce inflammatory cytokines that act specifically through receptors expressed by the brain, leading to the development of behavioral disorders including depressive behavior and cognitive alterations. These behavioral alterations cease along with the synthesis of brain cytokines. When the level of expression of these cytokines remains high, they become toxic to neurons and can lead to their death, as in the case of neurodegenerative disorders like Alzheimer’s disease. Omega3 (ω3) type polyunsaturated fatty acids (PUFAs) are essential nutrients and essential components of neuronal and glial cell membranes. Additionally, they have powerful immunomodulatory properties and regulate the cytokines and their signaling pathways. They accumulate in the brain during the perinatal period in a dietary supply-dependant fashion. Their brain levels diminish with age, but can be corrected by a diet enriched in ω3 PUFAs. The increasing exposure of the population to “fast-food” type diets, extremely unbalanced in ω3 PUFAs, could contribute to the fragilization of the brain with respect to cytokines.

This is a preview of subscription content, log in via an institution.

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 949.00; Price excludes VAT (USA)

Softcover Book: USD 1,199.99; Price excludes VAT (USA)

Hardcover Book: USD 1,199.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

15d-PGJ2:: 15-deoxy-delta 12,14-prostaglandin J2
AA:: Arachidonic acid
ALA:: Alpha linolenic acid
BBB:: Blood brain barrier
CNS:: Central nervous system
COX:: Cyclooxygenase
cPLA2:: Calcium-dependent phospholipase A2
DHA:: Docosahexaenoic acid
DPA:: Docosapentaenoic acid
EPA:: Eicosapentaenoic acid
ERK:: Extracellular signal-regulated protein kinase
GFAP:: Glial fibrillary acidic protein
HEPE:: Hydroxyeicosapentaenoic acid
IKK:: IκB kinase
IL-1:: Interleukin 1
IL-10:: Interleukin 10
IL-1R:: Interleukin 1 receptor
IL-1ra:: Interleukin 1 receptor antagonist
IL-1RAcP:: Interleukin 1 receptor accessory protein
IL-6:: Interleukin 6
IL-6R:: Interleukin 6 receptor
iPLA2:: Calcium-independent phospholipase A2
IRAK:: Interleukin-1 receptor associated kinase
IκB:: Inhibitor of κB
JAK:: Janus kinase
JNK:: c-Jun N-terminal kinase
LA:: Linoleic acid
LOX:: Lipoxygenase
LPS:: Lipopolysaccharide
LT:: Leukotriene
LTP:: Long-term potentiation
LXA4:: Lipoxin A4
LXR:: Liver X receptor
MAPK:: Mitogen associated protein (MAP) kinase
MHCII:: Class II major histocompatibility complex
MK:: MAPK-activated protein kinase
MyD88:: Myeloid differentiation primary response gene (88)
NEMO:: NFκB essential modulator
NFκB:: Nuclear factor kappa B
NIK:: NFκB inducing kinase
PAMP:: Pathogen-associated molecular patterns
PC:: Phosphatidylcholine
PE:: Phosphatidylethanolamine
PG:: Prostaglandin
PGE2:: Prostaglandin E2
PGI:: Prostacyclin
PPAR:: Peroxisome proliferator-activated receptor
PUFA:: Polyunsaturated fatty acid
RXR:: Retinoid X receptor
SAMP8:: Senescence-accelerated prone mouse
STAT:: Signal transducers and activators of transcription
TACE:: TNFα cleavage enzyme
TLR4:: Toll-like receptor 4
TNFR:: Tumor necrosis factor receptor
TNFα:: Tumor necrosis factor alpha
TRADD:: TNFR1-associated via death domain
TRAF-6:: TNF receptor associated factor 6
TX:: Thromboxane
Tyk:: Tyrosine kinase 2

References

Bas O, Songur A, Sahin O, Mollaoglu H, Ozen OA, Yaman M, Eser O, Fidan H, Yagmurca M. Neurochem Int. 2007;50:548–54.
Article PubMed CAS Google Scholar
Bourre JM, Piciotti M. Neurosci Lett. 1992;141:65–8.
Article PubMed CAS Google Scholar
Calder PC. Am J Clin Nutr. 2006;83:1505S–19S.
PubMed CAS Google Scholar
Calder PC. Biochimie. 2009;91:791–5.
Article PubMed CAS Google Scholar
Calon F, Cole G. Prostaglandins Leukot Essent Fatty Acids. 2007;77:287–93.
Article PubMed CAS Google Scholar
Chapkin RS, McMurray DN, Davidson LA, Patil BS, Fan YY, Lupton JR. Br J Nutr. 2008;100:1152–7.
Article PubMed CAS Google Scholar
Chavali SR, Zhong WW, Forse RA. Prostaglandins Leukot Essent Fatty Acids. 1998;58:185–91.
Article PubMed CAS Google Scholar
De Smedt-Peyrusse V, Sargueil F, Moranis A, Harizi H, Mongrand S, Layé S. J Neurochem. 2008;105:296–307.
Article PubMed CAS Google Scholar
Dyerberg J, Bang HO. Lancet. 1979;2:433–5.
Article PubMed CAS Google Scholar
Dziennis S, Alkayed NJ. Rev Neurosci. 2008;19:341–61.
Article PubMed CAS Google Scholar
Ericsson A, Liu C, Hart RP, Sawchenko PE. J Comp Neurol. 1995;361:681–98.
Article PubMed CAS Google Scholar
Favrelière S, Perault MC, Huguet F, De Javel D, Bertrand N, Piriou A, Durand G. Neurobiol. Aging. 2003;24:233–43.
Article PubMed Google Scholar
Ferrucci L, Cherubini A, Bandinelli S, Bartali B, Corsi A, Lauretani F, Martin A, Andres-Lacueva C, Senin U, Guralnik JM. J Clin Endocrinol Metab. 2006;91:439–46.
Article PubMed CAS Google Scholar
Gautron L, Lafon P, Chaigniau M, Tramu G, Layé S. Neuroscience. 2002;112:717–29.
Article PubMed CAS Google Scholar
Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW, Johnson RW. FASEB J. 2005;19:1329–31.
PubMed CAS Google Scholar
Griffin R, Nally R, Nolan Y, McCartney Y, Linden J, Lynch MA. J Neurochem. 2006;99:1263–72.
Article PubMed CAS Google Scholar
Harré EM, Roth J, Pehl U, Kueth M, Gerstberger R, Hübschle T. J Appl Physiol. 2002;92:2657–66.
PubMed Google Scholar
Jones SA, Richards PJ, Scheller J, Rose-John S. J Interferon Cytokine Res. 2005;25:241–53.
Article PubMed CAS Google Scholar
Kaur P, Heggland I, Aschner M, Syversen T. Neurotoxicology. 2008;29:978–87.
Article PubMed CAS Google Scholar
Kavanagh T, Lonergan PE, Lynch MA. Prostaglandins Leukot Essent Fatty Acids. 2004;70:391–7.
Article PubMed CAS Google Scholar
Kiecolt-Glaser JK, Belury MA, Porter K, Beversdorf DQ, Lemeshow S, Glaser R. Psychosom Med. 2007;69:217–24.
Article PubMed CAS Google Scholar
Konsman JP, Vigues S, Mackerlova L, Bristow A, Blomqvist A. J Comp Neurol. 2004;472:113–29.
Article PubMed Google Scholar
Legler DF, Micheau O, Doucey MA, Tschopp J, Bron C. Immunity. 2003;18:655–64.
Article PubMed CAS Google Scholar
Liu ZG. Cell Res. 2005;15:24–7.
Article PubMed CAS Google Scholar
Lukiw WJ, Cui JG, Marcheselli VL, Bodker M, Botkjaer A, Gotlinger K, Serhan CN, Bazan NG. J Clin Invest. 2005;115:2774–83.
Article PubMed CAS Google Scholar
Lynch AM, Loane DJ, Minogue AM, Clarke RM, Kilroy D, Nally RE, Roche OJ, O’Connell F, Lynch MA. Neurobiol Aging. 2007;28 (6):845–55.
Article PubMed CAS Google Scholar
Lynch AM, Lynch MA. Eur J Neurosci. 2002;15:1779–88.
Article PubMed Google Scholar
McCoy MK, Tansey MG. J Neuroinflammation. 2008;5:45.
Article PubMed Google Scholar
McGahon BM, Martin DS, Horrobin DF, Lynch MA. Neuroscience. 1999a;94:305–14.
Article PubMed CAS Google Scholar
McGahon BM, Murray CA, Horrobin DF, Lynch MA. Neurobiol Aging. 1999b;20:643–53.
Article PubMed CAS Google Scholar
Meydani SN, Endres S, Woods MM, Goldin BR, Soo C, Morill-Labrode A, Dinarello CA, Gorbach SL. J Nutrition. 1991;121:547-555.
Article PubMed CAS Google Scholar
Michaeli B, Berger MM, Revelly JP, Tappy L, Chiolero R. Clinical nutrition (Edinburgh, Scotland) 2007;26:70-77.
Article PubMed CAS Google Scholar
Miguelez M, Anisman H, Weber JM, Merali Z. J Neuroimmunol. 2006;181:19–28.
Article PubMed CAS Google Scholar
Mingam R, Moranis A, Bluthé RM, De Smedt-Peyrusse V, Kelley KW, Guesnet P, Lavialle M, Dantzer R, Layé S. Eur J Neurosci. 2008;28:1877–86.
Article PubMed Google Scholar
Minogue AM, Lynch AM, Loane DJ, Herron CE, Lynch MA. J Neurochem. 2007;103:914–26.
Article PubMed CAS Google Scholar
Nadjar A, Combe C, Layé S, Tridon V, Dantzer R, Amédée T, Parnet P. J Neurochem. 2003;87:1024–36.
Article PubMed CAS Google Scholar
Pertusa M, García-Matas S, Rodríguez-Farré E, Sanfeliu C, Cristòfol R. J Neurochem. 2007;101:794–805.
Article PubMed CAS Google Scholar
Petursdottir AL, Farr SA, Morley JE, Banks WA, Skuladottir GV. Neurobiol Aging. 2007;28:1170–8.
Article PubMed CAS Google Scholar
Pluess TT, Hayoz D, Berger MM, Tappy L, Revelly JP, Michaeli B, Carpentier YA, Chioléro RL. Intensive Care Med. 2007;33:789–97.
Article PubMed CAS Google Scholar
Rapoport SI, Rao JS, Igarashi M. Prostaglandins Leukot Essent Fatty Acids. 2007;776:251–61.
Article Google Scholar
Rees D, Miles EA, Banerjee T, Wells SJ, Roynette CE, Wahle KW, Calder PC. Am J Clin Nutr. 2006;83:331–42.
PubMed CAS Google Scholar
Rothwell NJ, Luheshi GN. Trends Neurosci. 2000;23:618–25.
Article PubMed CAS Google Scholar
Scher JU, Pillinger MH. Clin Immunol. 2005;114:100–9.
Article PubMed CAS Google Scholar
Sehgal PB, Guo GG, Shah M, Kumar V, Patel K. J Biol Chem. 2002;277:12067–74.
Article PubMed CAS Google Scholar
Serhan CN. Prostaglandins Leukot Essent Fatty Acids. 2008;79:157–63.
Article PubMed CAS Google Scholar
Simopoulos AP. World Rev Nutr Diet. 2009;99:1–16.
Article PubMed CAS Google Scholar
Song C, Horrobin D. J Lipid Res. 2004;45:1112–21.
Article PubMed CAS Google Scholar
Tancredi V, D’Antuono M, Cafè C, Giovedì S, Buè MC, D’Arcangelo G, Onofri F, Benfenati F. J Neurochem. 2000;75:634–43.
Article PubMed CAS Google Scholar
Triantafilou M, Miyake K, Golenbock DT, Triantafilou K. J Cell Sci. 2002;115:2603–11.
PubMed CAS Google Scholar
Ye SM, Johnson RW. J Neuroimmunol. 2001;117:87–96.
Article PubMed CAS Google Scholar

Download references

Acknowledgment

Supported by INRA, CNRS, University of Bordeaux 2, the region Aquitaine and ANR grant ALIA.

Author information

Authors and Affiliations

Psychoneuroimmunology, nutrition and genetics (Psynugen), Université Bordeaux 2, INRA, UMR1286, CNRS, UMR5226, Bâtiment UFR Pharmacie – 2ème Tranche – 2ème Etage, Case courrier 34, 146 rue Léo Saignat, 33076, BORDEAUX, Cedex, France
Sophie Laye

Authors

Sophie Laye
View author publications
You can also search for this author in PubMed Google Scholar
Virginie F. Labrousse
View author publications
You can also search for this author in PubMed Google Scholar
Veronique De Smedt-Peyrusse
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sophie Laye .

Editor information

Editors and Affiliations

Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom
Victor R. Preedy
Arizona Health Science Center, Mel and Enid Zuckerman College of Public, University of Arizona, 1501 N. Campbell Ave. Room 4335, Tucson, 85724-5155, Arizona, USA
Ronald Ross Watson
University of the West of Scotland, Ayr Campus, Ayr, KA8 0SR, United Kingdom
Colin R. Martin

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Laye, S., Labrousse, V.F., De Smedt-Peyrusse, V. (2011). Dietary n-3-Polyunsaturated Fatty Acid Deprivation and Cytokine Signaling Pathways in the Brain. In: Preedy, V., Watson, R., Martin, C. (eds) Handbook of Behavior, Food and Nutrition. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92271-3_115

Download citation

DOI: https://doi.org/10.1007/978-0-387-92271-3_115
Published: 31 January 2011
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-92270-6
Online ISBN: 978-0-387-92271-3
eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics