Abstract
Head injury does not consist of the primary injury alone, it also includes secondary type injury. Although primary brain injury is irreversible, it is not necessarily the cause of death. Morbidity and mortality often result from secondary brain injury. Within the brain, head injury effects are mediated by deleterious neurotransmitters such as glutamate, reactive oxygen species (ROS), and inflammatory processes governed by complement and cellular immunity. These damaging processes result in cerebral edema, brain cell metabolic dysfunction, and ultimately cell death due to energy failure. At the systemic level, extensive adaptations immediately follow head injury. They include inflammatory cascade; increase in catabolic and counterregulatory hormones, such as catecholamines, glucagon, and cortisol; and alterations in the hypothalamic–pituitary feedback mechanism. The consequences are alterations in whole-body metabolism such as hypermetabolism, hypercatabolism, hyperglycemia, diminished immunocompetence, altered gastric functioning, and increased endothelial permeability. These metabolic disturbances (in particular protein wasting) lead to a dysimmunity, which compromises clinical outcome and thereby increases morbidity and mortality. So far little attention has been paid to nutritional intervention as a potential treatment of head injury. However, nutrition may have many interests, among which preventing the wasting syndrome, preserving the immune function, restoring the gastrointestinal function, and improving the neurological outcome. Despite promising experimental and clinical results, there are not yet sufficient clinical trials to make nutritional recommendations in head injury patients. Therefore, the development of large trials is mandatory to determine which nutrient, at which dose, would be the most appropriate to positively influence head injury patients’ outcome.
Key words: Head trauma, nutritional management, hypermetabolism, dysimmunity, resistance to renutrition
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Abbreviations
- ATP:
-
Adenosine triphosphate
- DNA:
-
Deoxyribonucleic acid
- GCS:
-
Glasgow coma scale
- HI:
-
Head injury
- IED:
-
Immune-enhancing diet
- IGF-1:
-
Insulin-like growth factor-1
- IL1:
-
Interleukin-1
- IL6:
-
Interleukin-6
- IL8:
-
Interleukin-8
- IL10:
-
Interleukin-10
- RMR:
-
Resting metabolic rate
- RNA:
-
Ribonucleic acid
- ROS:
-
Reactive oxygen species
- Sir2α:
-
Mammalian silent information regulator
- TNFα :
-
Tumor necrosis factor-α
- 3-MH:
-
3-methylhistidine
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The authors wish to thank Geneviève Arnaud-Vincent from the Paris Descartes University Language Center for proofreading the English version of this chapter.
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Charrueau, C., Morio, B., Moinard, C. (2011). Head Injury: Metabolic, Nutritional, and Energy Considerations. In: Preedy, V., Watson, R., Martin, C. (eds) Handbook of Behavior, Food and Nutrition. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92271-3_103
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