Exercise, Appetite, and Energy Balance: The Interactions Between Energy Expenditure and Intake, and the Implications for Weight Management

  • Stephen Whybrow
  • Neil King
  • James Stubbs


A low level of physical activity, typical of Western society, is deemed conducive to weight gain, while an increase in physical activity tends to promote weight loss, suggesting an imperfect coupling between energy expenditure and intake. Conversely, individuals with high levels of habitual activity tend to be in energy balance over the long-term suggesting that intake is adjusted to match expenditure. There are four interactions to consider between energy intake and expenditure in the development and treatment of obesity. Does exercise drive energy intake upwards and undermine its contribution to weight management? Does sedentariness alter levels of energy intake or subsequent energy expenditure? Do high levels of energy intake alter physical activity or exercise? And does dieting elevate or decrease energy expenditure? Cross talk between elevated energy expenditure and intake is initially too weak and takes too long to activate, to seriously threaten dietary approaches to weight management. It appears that substantial fat loss is possible before intake begins to track a sustained elevation in expenditure. There is little evidence that sedentariness produces compensatory reductions in energy intake. This lack of cross talk between altered expenditure and intake tends to promote a positive energy balance. Sizeable, compensatory changes in nonexercise activity in response to overfeeding are feasible, but have yet to be clearly demonstrated. There is more evidence that energy intake restriction does lower physical activity levels (PALs) – at least when it is more severe and for longer than is recommended for normal dieting and weight loss. A higher level or duration of physical activity is needed to prevent weight regain after dieting than is needed to prevent weight gain in the first place. Even more is needed to achieve weight loss through exercise alone. Individuals who are regularly physically active tend to be leaner and have a lower body weight than those who are sedentary. Taking up regular exercise results in weight loss or maintenance, while stopping results in weight gain. However, individuals vary in their ability to adjust or regulate the various components of energy balance, and therefore in their resistance to lose or gain weight in response to increases or decreases in energy expenditure respectively.


Physical Activity Energy Expenditure Energy Intake Negative Energy Balance Daily Energy Expenditure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Diet induced thermogenesis


Non exercise activity thermogenesis


Physical activity level


Resting metabolic rate


  1. Bassuk SS, Manson JE. J Appl Physiol. 2005;99:1193–204.PubMedCrossRefGoogle Scholar
  2. Black AE, Coward WA, Cole TJ, Prentice AM. Eur J Clin Nutr. 1996;50:72–92.PubMedGoogle Scholar
  3. Blanc S, Normand S, Ritz P, Pachiauda C, Vico L, Gharib C, Gauquelin-Koch G. J Clin Endocrinol Metab. 1998;83:4289–97.PubMedCrossRefGoogle Scholar
  4. Blundell JE, King NA. Overconsumption as a cause of weight gain: behaviour-physiological interactions in the control of food intake (appetite). The origins and consequences of obesity. In: Chadwick DJ, Cardew G, editors. Chichester: Wiley; 1996. p. 138–58.Google Scholar
  5. Blundell JE, Stubbs RJ, Hughes DA, Whybrow S, King NA. Proc Nutr Soc. 2003;62:651–61.PubMedCrossRefGoogle Scholar
  6. Caudwell P, King NA, Hopkins M, Stubbs RJ, Naslund E, Blundell JE. Int J Obes. 2008;32:S24.CrossRefGoogle Scholar
  7. Cordain L, Gotshall RW, Boyd Eaton S, Boyd Eaton III S. Int J Sports Med. 1998;19:328–35.PubMedCrossRefGoogle Scholar
  8. Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK. Med Sci Sports Exerc. 2009;41:459–71.Google Scholar
  9. Doucet E, Imbeault P, St-Pierre S, Alméras N, Mauriège P, Richard D, Tremblay A. Int J Obes Relat Metab Disord. 2000;24:906–14.PubMedCrossRefGoogle Scholar
  10. Elia M, Stratton R, Stubbs RJ. Proc Nutr Soc. 2003;62:529–37.PubMedCrossRefGoogle Scholar
  11. Forbes GB, Brown MR, Welle SL, Lipinski BA. Br J Nutr. 1986;56:1–9.PubMedCrossRefGoogle Scholar
  12. Gibney ER. The physical, psychological and metabolic effects of nutritional depletion and subsequent repletion. Cambridge: University of Cambridge; 2001.Google Scholar
  13. Gore SA, Foster JA, DiLillo VG, Kirk K, Smith West D. Eat Behav. 2003;4:399–405.PubMedCrossRefGoogle Scholar
  14. Haines A, McMichael T, Anderson R, Houghton J. Br Med J. 2000;321:1168–9.CrossRefGoogle Scholar
  15. Harris AM, Jensen MD, Levine JA. Obesity 2006;14:690–5.PubMedCrossRefGoogle Scholar
  16. Hill JO, Wyatt HR, Reed GW, Peters JC. Science 2003;299:853–5.PubMedCrossRefGoogle Scholar
  17. Hubert P, King NA, Blundell JE. Appetite 1998;31:9–19.PubMedCrossRefGoogle Scholar
  18. Jakicic JM, Marcus BH, Lang W, Janney C. Arch Intern Med. 2008;168:1550–9.PubMedCrossRefGoogle Scholar
  19. Jebb SA, Prentice AM. Proc Nutr Soc. 1995;54:721–8.PubMedCrossRefGoogle Scholar
  20. Jeffery RW, Rick AM. Obes Res. 2002;10:809–15.PubMedCrossRefGoogle Scholar
  21. Johnstone AM. Weight loss in human obesity. Aberdeen: University of Aberdeen; 2002.Google Scholar
  22. Johnstone AM. Obes Rev. 2007;8:211–22.PubMedCrossRefGoogle Scholar
  23. Johnstone AM, Faber P, Gibney ER, Elia M, Horgan G, Golden BE, Stubbs RJ. Int J Obes. 2002;26:1623–8.CrossRefGoogle Scholar
  24. Kant AK, Schatzkin A, Graubard BI, Ballard Barbash R. Int J Obes. 1995;19:468–74.Google Scholar
  25. Kempen KPG, Saris WHM, Westerterp KR. Am J Clin Nutr. 1995;62:722–9.PubMedGoogle Scholar
  26. King NA, Tremblay A, Blundell JE. Med Sci Sports Exerc. 1997;29:1076–89.PubMedCrossRefGoogle Scholar
  27. King NA., Caudwell P, Hopkins M, Byrne NM, Colley R, Hills AP, Stubbs JR, Blundell JE. Obesity 2007;15:1373–83.PubMedCrossRefGoogle Scholar
  28. King NA, Hopkins M, Caudwell P, Stubbs RJ, Blundell JE. Int J Obes. 2008;32:177–84.CrossRefGoogle Scholar
  29. Leonard WR, Galloway VA, Ivakine E. Am J Phys Anthropol. 1997;103:443–54.PubMedCrossRefGoogle Scholar
  30. Levine JA, Eberhardt NL, Jensen MD. Science 1999;283:212–4.PubMedCrossRefGoogle Scholar
  31. Levine JA, Schleusner SJ, Jensen MD. Am J Clin Nutr. 2000;72:1451–4.PubMedGoogle Scholar
  32. Long SJ, Hart K, Morgan LM. Br J Nutr. 2002;87:517–23.PubMedCrossRefGoogle Scholar
  33. Martinez-Gonzalez MA, Martinez JA, Hu FB, Gibney MJ, Kearney J. Int J Obes. 1999;23:1192–201.CrossRefGoogle Scholar
  34. Martins C, Truby H, Morgan LM. Br J Nutr. 2007;98:834–42.PubMedGoogle Scholar
  35. Mayer J, Roy P, Mitra KP. Am J Clin Nutr. 1956;4:169–74.PubMedGoogle Scholar
  36. Miller WC, Koceja DM, Hamilton EJ. Int J Obes. 1997;21:941–7.CrossRefGoogle Scholar
  37. Murgatroyd PR, Goldberg GR, Leahy FE, Gilsenan MB, Prentice AM. Int J Obes. 1999;23:1269–75.CrossRefGoogle Scholar
  38. Ogden J, Stavrinaki M, Stubbs J. Psychol Health Med. 2009;14:239–49.PubMedCrossRefGoogle Scholar
  39. Prentice AM, Jebb SA. BMJ 1995;311:437–9.PubMedCrossRefGoogle Scholar
  40. Racette SB, Schoeller DA, Kushner RF, Neil KM, Herling-Iaffaldano K. Am J Clin Nutr. 1995;61:486–91.PubMedGoogle Scholar
  41. Ritz P, Maillet A, Blanc S, Stubbs RJ. Clin Nutr. 1999;18:203–7.PubMedCrossRefGoogle Scholar
  42. Saris WHM, van Erp-Baart MA, Brouns F, Westerterp KR, ten Hoor F. Int J Sports Med. 1989;10:S26–31.PubMedCrossRefGoogle Scholar
  43. Saris WHM, Blair SN, van Baak MA, Eaton SB, Davies PSW, Di Pietro L, Fogelholm M, Rissanen A, Schoeller D, Swinburn B, Tremblay A, Westerterp KR, Wyatt H. Obes Rev. 2003;4:101–14.PubMedCrossRefGoogle Scholar
  44. Shepard TY, Weil KM, Sharp TA, Grunwald GK, Bell ML, Hill JO, Eckel RH. Am J Clin Nutr. 2001;73:703–8.PubMedGoogle Scholar
  45. Stubbs RJ, Johnstone AM, O’Reilly LM, Barton K, Reid C. Int J Obes. 1998;22:980–7.CrossRefGoogle Scholar
  46. Stubbs RJ, Sepp A, Hughes DA, Johnstone AM, Horgan GW, King N, Blundell J. Eur J Clin Nutr. 2002a;56:129–40.PubMedCrossRefGoogle Scholar
  47. Stubbs RJ, Sepp A, Hughes DA, Johnstone AM, King N, Horgan G, Blundell JE. Int J Obes. 2002b;26:866–9.CrossRefGoogle Scholar
  48. Stubbs RJ, Hughes DA, Johnstone AM, Horgan GW, King N, Elia M, Blundell JE. Interactions between energy intake and expenditure in the development and treatment of obesity. In: Medeiro-Neto G, Halpern A, Bouchard C, editors. Progress in obesity research 9. Surrey: John Libbey Eurotext; 2003.Google Scholar
  49. Stubbs RJ, Hughes DA, Johnstone AM, Horgan GW, King N, Blundell JE. Am J Clin Nutr. 2004;79:62–9.PubMedGoogle Scholar
  50. Temple JL, Giacomelli AM, Kent KM, Roemmich JN, Epstein LH. Am J Clin Nutr. 2007;85:355–61.PubMedGoogle Scholar
  51. Tremblay A, Doucet E. Proc Nutr Soc. 1999;58:99–105.PubMedCrossRefGoogle Scholar
  52. Tremblay A, Despres JP, Theriault G, Fourier G, Bouchard C. Am J Clin Nutr. 1992;56:857–62.PubMedGoogle Scholar
  53. Verger P, Lanteaume MT, Louis-Sylvestre J. Appetite 1992;18:93–9.PubMedCrossRefGoogle Scholar
  54. Warburton DER, Nicol CW, Bredin SSD. CMAJ 2006;174:801–9.PubMedCrossRefGoogle Scholar
  55. Westerterp KR. Am J Clin Nutr. 1998;68:970S–4S.PubMedGoogle Scholar
  56. Whybrow S, Hughes DA, Ritz P, Johnstone AM, Horgan GW, King N, Blundell JE, Stubbs RJ. Br J Nutr. 2008;100:1109–15.PubMedCrossRefGoogle Scholar
  57. Williams PT, Thompson PD. Obesity 2006;14:1975–84.PubMedCrossRefGoogle Scholar
  58. Wing RR, Phelan S. Am J Clin Nutr. 2005;82(suppl):222S–5S.PubMedGoogle Scholar
  59. Woo R, Pi-Sunyer FX. Metab Clin Exp. 1985;34:836–41.PubMedCrossRefGoogle Scholar
  60. Wu T, Gao X, Chen M, van Dam RM. Obes Rev. 2009;10:313–323.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Faculty of Health and Medical SciencesUniversity of SurreyGuildfordUK

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