Two-dimensional, two-QTL scans

  • Karl W. Broman
  • Śaunak Sen
Part of the Statistics for Biology and Health book series (SBH)

Most complex traits are understood to be the result of the action of multiple genetic loci. Some loci may be linked, and the effect of some loci may depend on the genotype at others (epistasis). In this chapter, we undertake the first step in the direction of teasing apart the multiple linked or interacting QTL underlying a quantitative trait, by contemplating two-dimensional, two-QTL genome scans.


Binary Trait Left Triangle Hyper Data Miss Genotype Data Knott Regression 
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Copyright information

© Springer-Verlag New York 2009

Authors and Affiliations

  1. 1.Dept. Biostatistics & Medical InformaticsUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.Dept. Epidemiology & BiostatisticsUniversity of California San FranciscoSan FranciscoUSA

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