A 78-year-old man presented with a skin nodule on the forehead. The lesion grew rapidly over a period of two months. Physical examination showed a 3 × 3 cm firm exophytic erythematous papule with very shallow overlying excoriation on the left forehead. A full skin check did not reveal any other lesion. There was neither palpable lymphadenopathy nor hepatosplenomegaly. A CT scan of chest and abdomen also showed no lymphadenopathy. A 4-mm punch skin biopsy was performed (Fig. 63.1). In the follow-up visit one month later, the patient claimed that the skin nodule was enlarged and two new small nodules appeared.
KeywordsAnaplastic Large Cell Lymphoma Skin Nodule Punch Skin Biopsy Lymphomatoid Papulosis Palpable Lymphadenopathy
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- 2.Ralfkiaer E, Willemze R, Paulli M, et al. Primary cutaneous CD30-positive T-cell lymphoproliferative disorders. In Swerdlow SH, Campo E, Harris NL, et al. eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France, IARC Press, 2008, 300–301.Google Scholar
- 3.Kato N, Mizuno O, Ito K, et al. Neutrophil-rich anaplastic large cell lymphoma presenting in the skin. Am J Dermatopathol 2003;25:142–147.Google Scholar
- 4.Kadin ME, Pinkus JL, Pinkus GS, et al. Primary cutaneous ALCL with phosphorylated/activated cytoplasmic ALK and novel phenotype: EMA/MUC1+. cutaneous lymphocyte antigen negative. Am J Surg Pathol 2008; 32:1421–1426.Google Scholar