Skip to main content
  • 1886 Accesses

A 39-year-old man presented with progressive skin lesions on his trunk associated with constitutional symptoms for six months. He had arthralgias, bone pain in the ankles and wrists, fatigue, fever, and a 20-pound weight loss over a period of six months. He was treated with a short course of antibiotics without benefit. Physical examination revealed diffused subcutaneous nodules of varying sizes over his trunk with the largest nodule measuring 4 cm. Lymphadenopathy and hepatosplenomegaly were not detected. Laboratory test results, including liver function tests and hematology workup, were within normal ranges. A skin biopsy showed tumor cell infiltration (Figs. 61.1 and 61.2). Subsequently, a bone marrow biopsy was performed (Figs. 61.3 and 61.4).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brody JP, Allen S, Schulman P, Sun T, et al. Acute agranular CD4-positive natural killer cell leukemia. Comprehensive clinicopathologic studies including virologic and in vitro culture with inducing agents. Cancer 1995;75:2474–2483.

    Google Scholar 

  2. Petrella T, Meijer CJLM, Dalac S, et al. TCL1 and CLA expression in agranular CD4/CD56 hematodermic neoplasms (blastic NK-cell lymphomas) and leukemia cutis. Am J Clin Pathol 2004;122:307–313.

    Article  CAS  PubMed  Google Scholar 

  3. Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005;105:3768–3785.

    Article  CAS  PubMed  Google Scholar 

  4. Facchetti F, Jones DM, Petrella T. Blastic plasmacytoid dendritic cell neoplasm. In Swerdlow SH, Campo E, Harris NL, et al. eds., WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th ed., Lyon, France, IARC Press, 2008, 145–147.

    Google Scholar 

  5. Ferran M, Gallardo F, Ferrer AM, et al. Acute myeloid dendritic cell leukemia with specific cutaneous involvement: a diagnostic challenge. Br J Dermatol 2008;158:1129–1133.

    Article  CAS  PubMed  Google Scholar 

  6. Garnache-Ottou F, Feuillard J, Saas P. Plasmacytoid dendritic cell leukemia/lymphoma: toward a well defined entity? Br J Haematol 2007;136:539–548.

    Article  CAS  PubMed  Google Scholar 

  7. Herling M, Jones D. CD4+/CD56+ hematodermic tumor: The features of an evolving entity and its relationship to dendritic cells. Am J Clin Pathol 2007;127:687–700.

    Article  PubMed  Google Scholar 

  8. Marafioti T, Paterson JC, Ballabio E, et al. Novel markers of normal and neoplastic human plasmacytoid dendritic cells. Blood 2008;111:3778–3792.

    Article  CAS  PubMed  Google Scholar 

Download references

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

(2009). Case 61. In: Sun, T. (eds) Atlas of Hematologic Neoplasms. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-89848-3_62

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-89848-3_62

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-89847-6

  • Online ISBN: 978-0-387-89848-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics