A 64-year-old man presented with a rapidly growing cutaneous mass on the right leg. He was diagnosed plasma cell myeloma six years ago with multiple osteolytic bone lesions in the frontal parietal bones, right distal ulnar, left femur, and L4 vertebral body. Immunoglobulin studies confirmed the diagnosis of lambda light chain disease. He subsequently developed a metastatic lesion in the nasopharynx. The histologic features of the skin biopsy are illustrated in Figs. 37.1 and 37.2.


Distal Ulnar Lambda Light Chain Plasma Cell Myeloma Extramedullary Plasmacytoma Solitary Plasmacytoma 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Weber DM. Solitary bone and extramedullary plasmacytoma. Hematology, Am Soc Hematol Educ Program 2005; 373–376.Google Scholar
  2. 2.
    McKenna RW, Kyle RA, Kuehl WM, et al. Plasma cell neoplasms, In Swerdlow SH, Campo E, Harris NL, et al. eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed., Lyon, France, IARC Press, 2008; 200–213.Google Scholar
  3. 3.
    Dimophoulos MA, Kiamouris C, Moulopoulos LA. Solitary plasmacytoma of bone and extramedullary plasmacytoma. Hematol Oncol Clin North Am 1999;13:1249–1257.CrossRefGoogle Scholar
  4. 4.
    The International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749–757.Google Scholar
  5. 5.
    Damaj G, Mohty M, Vey N, et al. Features of extramedullary and extraosseous multiple myeloma: a report of 19 patients from a single center. Eur J Haematol 2004;73:402–406.CrossRefPubMedGoogle Scholar
  6. 6.
    Requena L, Kutzner H, Palmedo G, et al. Cutaneous involvement in multiple myeloma. Arch Dermatol 2003;139:475–486.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Personalised recommendations