A 59-year-old man presented with abdominal discomfort, early satiety, and easy fatigability for several months. Physical examination revealed splenomegaly and cervical lymphadenopathy, but the liver was not palpable. Hematology workup showed a total leukocyte count of 117,000/μl with 80.5% lymphocytes, 14.3% neutrophils, and 2.8% monocytes. A manual differential count demonstrated 60% prolymphocytes in the lymphoid population (Fig. 30.1). His hematocrit was 41%, hemoglobin 12.5 g/dl, and platelets 140,000/μl. After admission, bone marrow (Figs. 30.2 and 30.3) and lymph node (Figs. 30.4 and 30.5) biopsies were performed.


Chronic Lymphocytic Leukemia Mantle Cell Lymphoma Chronic Lymphocytic Leukemia Cell TP53 Gene Total Leukocyte Count 
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