A 59-year-old man presented with abdominal discomfort, early satiety, and easy fatigability for several months. Physical examination revealed splenomegaly and cervical lymphadenopathy, but the liver was not palpable. Hematology workup showed a total leukocyte count of 117,000/μl with 80.5% lymphocytes, 14.3% neutrophils, and 2.8% monocytes. A manual differential count demonstrated 60% prolymphocytes in the lymphoid population (Fig. 30.1). His hematocrit was 41%, hemoglobin 12.5 g/dl, and platelets 140,000/μl. After admission, bone marrow (Figs. 30.2 and 30.3) and lymph node (Figs. 30.4 and 30.5) biopsies were performed.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Schlette E, Bueso-Ramos C, Giles F, et al. Mature B-cell leukemia with more than 55% prolymphocytes: A heterogeneous group that includes an unusual variant of mantle cell lymphoma. Am J Clin Pathol 2001;115:571–581.
Campo E, Catovsky D, Montserrat E, et al. B-cell prolymphocytic leukaemia. In Swerdlow SH, Campo E, Harris NL, et al. eds. WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. 4th ed., Lyon, France, IARC Press, 2008, 183–184.
Catovsky D, Müller-Hermelink HK, Ralfkiaer E. T-cell prolymphocytic leukemia. In Swerdlow SH, Campo E, Harris NL, et al. eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th ed., Lyon, France, IARC Press, 2008, 270–271.
Brunning RD, McKenna RW. Tumor of the Bone Marrow, Washington, DC, Armed Forces Institute of Pathology, 1994, 266–301.
Valbuena JR, Herling M, Admirand JH, et al. T-cell prolymphocytic leukemia involving extramedullary sites. Am J Clin Pathol 2005;123: 456–464.
Darden CD. T-cell prolymphocytic leukemia. Med Oncol 2006;23:17–22.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
(2009). Case 30. In: Sun, T. (eds) Atlas of Hematologic Neoplasms. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-89848-3_31
Download citation
DOI: https://doi.org/10.1007/978-0-387-89848-3_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-89847-6
Online ISBN: 978-0-387-89848-3
eBook Packages: MedicineMedicine (R0)