A 72-year-old man was found to have an enlarged cervical lymph node in a routine physical checkup. He denied having fever, night sweats and weight loss. Physical examination showed no hepatosplenomegaly. CT scan revealed no deep-seated lymphadenopathy. Peripheral blood examination demonstrated a total leukocyte count of 4,500/μl with 72% neutrophils, 23% lymphocytes, 4% monocytes, and 1% eosinophils. His hematocrit was 40%, hemoglobin 13 g/dl, and platelets 152,000/μl. A bone marrow aspirate showed 9% lymphocytes and the core biopsy revealed no lymphoid infiltrate. A lymph node biopsy was performed (Figs. 28.1 and 28.2).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Müller-Hermelink HK, Montserrat E, Catovsky D, et al. Chronic lymphocytic leukaemia/small lymphocytic lymphoma. In Swerdlow SH, Campo E, Harris NL, et al. eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France, IARC Press, 2008, 180–182.
Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the the National Cancer Institute-Working Group 1996 guidelines. Blood 2008;111:5446–5455.
Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms. A proposal from the International Lymphoma Study Group. Blood 1994;84:1361–1392.
Feller AC, Diebold J. Histopathology of Nodal and Extranodal Non-Hodgkin Lymphoma. 3rd ed., Berlin, Springer, 2004, 23–29.
Ghobrial IM, Bone ND, Stenson MJ, et al Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Mayo Clin Proc 2004;79:318–325.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
(2009). Case 28. In: Sun, T. (eds) Atlas of Hematologic Neoplasms. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-89848-3_29
Download citation
DOI: https://doi.org/10.1007/978-0-387-89848-3_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-89847-6
Online ISBN: 978-0-387-89848-3
eBook Packages: MedicineMedicine (R0)