A 5-year-old boy presented with nose bleeding, fever and fatigue for one week. Physical examination showed petechiae over his trunk and upper extremities. His cervical and axillary lymph nodes were palpable, but his liver and spleen were not enlarged. Chest X-ray examination shows no mediastinal mass. His peripheral blood showed a total leukocyte count of 21,500/μl with 30% blasts (Fig. 24.1). His hematocrit was 32%, hemoglobin 10 g/dl, and platelets 10,000/dl. The bone marrow biopsy demonstrated 62% blasts (Figs. 24.2 and 24.3).


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Notch Signaling Bone Marrow Biopsy Terminal Deoxynucleotidyl Transferase 
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