A 54-year-old man presented with a nodular lesion on the left neck at the site of a previous arterial line placement. It was originally considered a keloid. Upon consultation, the dermatologist suspected malignancy and a skin biopsy was performed (Figs. 22.1 and 22.2). Because of the histologic pattern, peripheral blood was studied and showed a total leukocyte count of 11,600/μl with 69% neutrophils, 10% lymphocytes and 19% monocytes including about 5% immature forms. His hemoglobin was 11.9 g/dl, hematocrit 36.9% and platelets 270,000/μl. This raised the suspicion of leukemia and a bone marrow biopsy was performed (Figs. 22.3 and 22.4).


Acute Myeloid Leukemia Acute Leukemia Bone Marrow Biopsy Total Leukocyte Count Monocytic Leukemia 
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  1. 1.
    Gil-Mateo MP, Miquel FJ, Piris MA, et al. Aleukemic “leukemia cutis” of monocytic lineage. J Am Acad Dermatol 1997;36:837–840.CrossRefPubMedGoogle Scholar
  2. 2.
    Cibull TL, Thomas AB, O’Malley DP, et al. Myeloid leukemia cutis: a histologic and immunohistochemical review. J Cutan Pathol 2008;35:180–185.PubMedGoogle Scholar
  3. 3.
    Chen L, Rodgers TR, Chaffins ML, et al. Acute monocytic leukemia with cutaneous manifestation. Arch Pathol Lab Med 2005;129:425–426.PubMedGoogle Scholar
  4. 4.
    Yavorkovsky LL, Zain J, Wu CD, et al. Monocytic leukemia cutis diagnosed simultaneously with refractory anemia with monocytosis: A case report. Am J Hematol 2001;66:120–122.CrossRefPubMedGoogle Scholar
  5. 5.
    Sepp N, Radaszkiewicz T, Meijer CJLM, et al. Specific skin manifestations in acute leukemia with monocytic differentiation. Cancer 1993;71:124–132.CrossRefPubMedGoogle Scholar
  6. 6.
    Alexiev BA, Wang W, Ning Y, et al. Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study. Diagn Pathol 2007;2:1–8.CrossRefGoogle Scholar
  7. 7.
    Kuwabara H, Nagai M, Yamaoka G, et al. Specific skin manifestations in CD56 positive acute myeloid leukemia. J Cutan Pathol 1999;26:1–5.CrossRefPubMedGoogle Scholar

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