A 50-year-old man was evaluated for pallor and easy bruisability. Laboratory studies revealed hemoglobin 7.2 g/dl, hematocrit 21%, platelets 15,000/μl, and leukocyte count 7,100/μl with 62% lymphocytes and rare (<1%) blasts. Physical examination revealed petechiae, and no organomegaly or lymphadenopathy. The bone marrow aspirate was a dry tap but the bone marrow imprint showed a few blasts (Fig. 20.1). The bone marrow biopsy was suspicious for acute leukemia (Figs. 20.2 and 20.3). A second attempt finally obtained a diagnostic aspirate (Fig. 20.4).


Down Syndrome Bone Marrow Biopsy Bone Marrow Aspirate Hematologic Neoplasm Down Syndrome Patient 
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  1. 1.
    Arber DA, Brunning RD, Orazi A, et al. Acute myeloid leukaemia, not otherwise specified. In Sewerdlow SH Campo E, et al. eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed., Lyon, France, IARC Press, 2008, 136–137.Google Scholar
  2. 2.
    Sun T. Flow Cytometry and Immunohistochemistry for Hematologic Neoplasms. Philadelphia, Lippincott Williams & Wilkins, 2008, {122–129}.Google Scholar
  3. 3.
    Brink DS. Transient leukemia (transient myeloproliferative disorder, transient abnormal myelopoiesis) of Down syndrome. Adv Anat Pathol 2006;13:256–262.CrossRefPubMedGoogle Scholar
  4. 4.
    Vyas P, Crispino JD. Molecular insights into Down syndrome-associated leukemia. Curr Opin Pediatr 2007;19:9–14.CrossRefPubMedGoogle Scholar
  5. 5.
    Dastugue N, Lafage-Pochitaloff M, Pages MP, et al. Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): A study of the Groupe Francais de Cytogënëtique Hëmatologique (GFCH). Blood 2002;100:618–626.CrossRefPubMedGoogle Scholar

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