Pleomorphic adenomas are benign neoplasms with mixed epithelial and mesenchymal components that may be endobronchial or parenchymal. They are derived from seromucinous glands of the airway and are similar to those seen in major salivary glands. These tumors are more frequent in men by a factor of about 2:1 with a mean age of 50 years. Productive cough and intermittent dyspnea are manifestations of tracheal tumors. Other symptoms are wheezing, respiratory infection, and rarely hemoptysis. Parenchymal tumors may be clinically silent. Large endobronchial tumors may cause atelectasis, volume loss, or post-obstructive pneumonitis. CT scanning can assist with determination of extension of a tumor from the airways into the pulmonary parenchyma.