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Sarcomatoid Carcinoma

  • Shanda Blackmon
  • Armin Ernst
  • Philip T. Cagle
  • Timothy C. Allen
  • Dina R. Mody
  • Armando E. Fraire
Chapter

Abstract

Sarcomatoid carcinomas are currently listed separately by the WHO as a distinct category of malignant lung tumors. This group of carcinomas encompass some epithelial pseudo sarcomatous carcinomas as well as tumors with true sarcomatous components such as carcinosarcoma. In this atlas we cover two variants of sarcomatoid carcinoma: Giant Cell Carcinoma and Spindle Cell Carcinoma. Both known to be fast growing, clinically aggressive tumors with a propensity to present in advanced stage and to have a rather poor prognosis. Their radiographic presentation is non specific and their cytopathologic features are not well defined, although identification of large bizarre strap cells in cytologic preparations can be a clue for the diagnosis. The histopathology of giant cell carcinoma is highly distinctive. It is made of highly pleomorphic mono or multinucleated giant cells lacking evidence of any squamous or glandular features. Typically, an important inflammatory component, usually neutrophilic, can be found within these tumors.

Keywords

Multinucleated Giant Cell Sarcomatoid Carcinoma Spindle Cell Carcinoma Cytologic Preparation Pleomorphic Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Shanda Blackmon
    • 1
  • Armin Ernst
    • 2
  • Philip T. Cagle
    • 3
  • Timothy C. Allen
    • 4
  • Dina R. Mody
    • 5
  • Armando E. Fraire
    • 6
  1. 1.The Methodist HospitalHoustonUSA
  2. 2.Harvard Medical School, The Beth Israel Deaconess Medical CenterBostonUSA
  3. 3.Weill Medical College, The Methodist Hospital, Cornell UniversityHoustonUSA
  4. 4.The University of Texas Health Science Center at TylerTylerUSA
  5. 5.Weill Medical College, The Methodist Hospital, Cornell UniversityHoustonUSA
  6. 6.University of Massachusetts Medical SchoolWorcesterUSA

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