Large Cell Carcinoma
This carcinoma represents about 10% of all lung cancers. Microscopically, its main feature is the high level of malignancy and lack of squamous or glandular features. However, on electron microscopy, features of either adenocarcinoma or squamous cell can be appreciated suggesting that large cell carcinomas are basically poorly differentiated adenocarcinomas or squamous cell carcinomas. Nonetheless, the clinical presentation and the radiographic appearance more closely resemble adenocarcinoma. The endoscopic appearance is not distinctive since most large cell carcinomas do not involve the proximal airways. Most present as fleshy hemorrhagic-looking masses such as those shown in this chapter.