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Diffuse Large B-Cell Lymphoma

  • Shanda Blackmon
  • Armin Ernst
  • Philip T. Cagle
  • Timothy C. Allen
  • N. Paul Ohori
  • Elise R. Hoff
  • Armando E. Fraire
Chapter

Abstract

The high-grade non-Hodgkin lymphoma is characterized by a diffuse proliferation of large neoplastic B cells, typically showing nuclear size equal to or greater than the size of a normal macrophage. It is the second most common pulmonary lymphoma after maltoma. It occurs in a wide age range from children to adults. Patients are usually symptomatic. Grossly, the lesions are nodular in configuration and show no lobar predilection. Histopathologically, the process is highly distinctive involving both the pleura and the vascular system of the lung, features that can also be observed in imaging studies of the chest. The underlying lung architecture is usually obliterated, often with necrosis. In some cases, the neoplastic lymphoma cells occupy the alveolar spaces, a pneumonic-like process that has been termed tumoral pneumonia.

Keywords

Hodgkin Lymphoma Alveolar Space Nuclear Size World Health Organization Classification Pulmonary Pathology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Shanda Blackmon
    • 1
  • Armin Ernst
    • 2
  • Philip T. Cagle
    • 3
  • Timothy C. Allen
    • 4
  • N. Paul Ohori
    • 5
  • Elise R. Hoff
    • 5
  • Armando E. Fraire
    • 6
  1. 1.The Methodist HospitalHoustonUSA
  2. 2.Harvard Medical School, The Beth Israel Deaconess Medical CenterBostonUSA
  3. 3.Weill Medical College, The Methodist Hospital, Cornell UniversityHoustonUSA
  4. 4.The University of Texas Health Science Center at TylerTylerUSA
  5. 5.University of Pittsburgh Medical CenterPittsburghUSA
  6. 6.University of Massachusetts Medical SchoolWorcesterUSA

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