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Marginal Zone B-Cell Lymphoma (Maltoma)

  • Shanda Blackmon
  • Philip T. Cagle
  • Timothy C. Allen
  • N. Paul Ohori
  • Elise R. Hoff
  • Armando E. Fraire
Chapter

Abstract

A low-grade lymphoma, maltoma, represents a form of marginal zone lymphoma arising from mucosal (bronchial) associated lymphoid tissue. Maltomas may arise de novo or be preceded by autoimmune disorders of the lung. Radiographically, maltoma may present as single or multiple nodular masses involving one or both lungs. Airways are usually not affected by these tumors and are likely to remain intact, appearing as air bronchograms on high-resolution CT of the chest. Although not readily visualized endoscopically, a rare maltoma may be diagnosed by endoscopic or transbronchial biopsy. The main histopathologic constituents of maltoma are lymphoid cells resembling small lymphocytes, centrocytes, monocytoid B cells, and lymphoplasmacytic cells, generally with a low level of cellular atypia. An important histopathologic feature of these lesions is involvement of airway epithelium by lymphoid cells, the so-called lymphoepithelial lesion. Cytologically, a mixture of small and large lymphocytes with low level of cellular atypia may be seen.

Keywords

Lymphoid Cell Airway Epithelium Mucosal Associate Lymphoid Tissue Marginal Zone Lymphoma Small Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Shanda Blackmon
    • 1
  • Philip T. Cagle
    • 2
  • Timothy C. Allen
    • 3
  • N. Paul Ohori
    • 4
  • Elise R. Hoff
    • 4
  • Armando E. Fraire
    • 5
  1. 1.The Methodist HospitalHoustonUSA
  2. 2.Weill Medical College, The Methodist Hospital, Cornell UniversityHoustonUSA
  3. 3.The University of Texas Health Science Center at TylerTylerUSA
  4. 4.University of Pittsburgh Medical CenterPittsburghUSA
  5. 5.University of Massachusetts Medical SchoolWorcesterUSA

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