Inflammatory Pseudotumor

  • Philip T. Cagle
  • Timothy C. Allen
  • Armando E. Fraire


Two variants of this still poorly understood pulmonary lesion are recognized: an adult, most likely non-neoplastic variant, and a variant much more prone to occur in younger individuals, most likely neoplastic. The first variant, illustrated here, is widely believed to be the result of an unresolved inflammatory process similar in some respects to a localized form of organizing pneumonia. Features supporting a neoplastic nature for the second variant are its propensity to involve neighboring structures, cellular atypia, myofibroblastic proliferation, and immunopositivity for ALK-1 and p80. The main histopathologic characteristic of the adult form is the presence of spaces filled by plump fibroblasts without atypia and foamy histiocytes. Radiographic appearances on chest films vary from nodular to diffuse lung lesions. The endoscopic and cytopathologic features of inflammatory pseudotumors are not well defined


Neighboring Structure Pulmonary Lesion Radiographic Appearance Cellular Atypia Chest Film 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Philip T. Cagle
    • 1
  • Timothy C. Allen
    • 2
  • Armando E. Fraire
    • 3
  1. 1.Weill Medical College, The Methodist Hospital, Cornell UniversityHoustonUSA
  2. 2.The University of Texas Health Science Center at TylerTylerUSA
  3. 3.University of Massachusetts Medical SchoolWorcesterUSA

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