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Basic Concepts of Molecular Pathology pp 55–60Cite as

Bioinformatics and Omics

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Part of the book series: Molecular Pathology Library ((MPLB,volume 2))

Abstract

Bioinformatics has become an essential part of omics research and requires unique practical and analytical skills for appropriate results interpretation. Bioinformatics uses computers and statistics to perform extensive omics-related research by searching biological databases and comparing gene sequences and protein on a vast scale to identify sequences or proteins that differ between diseased and healthy tissues, or between different phenotypes of the same disease.30–37 The techniques used in omics are called high throughput because they involve analysis of very large numbers of genes, gene expression, or proteins in one procedure or combination of procedures. The vast amounts of data generated by these high-throughput studies typically require computers for analysis and comparison of differences between diseased and physiological cells and tissues, a key feature of bioinformatics. Omics and bioinformatics are used not only for the study of the genes and signaling pathways involved in human diseases, but also for identifying potential targets of therapy and the design of therapeutic drugs.

Omics – a suffix signifying the measurement of the entire complement of a given level of biological molecules and information – today encompasses a variety of new technologies that can help explain normal and abnormal cell pathways, networks, and processes via the simultaneous monitoring of thousands of molecular components.6,7

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  1. Department of Pathology, University of Texas Health Science Center at Tyler, Tyler, TX, USA

    Timothy Craig Allen

  2. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, USA

    Philip T. Cagle

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    Allen, T.C., Cagle, P.T. (2009). Bioinformatics and Omics. In: Allen, T., Cagle, P.T. (eds) Basic Concepts of Molecular Pathology. Molecular Pathology Library, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-89626-7_6

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