Prostate Cancer Stem Cells

  • Elaine M. Hurt
  • George J. Klarmann
  • Brian T. Kawasaki
  • Nima Sharifi
  • William L. Farrar


Prostate cancer is the leading cancer diagnosed in males. Emerging data suggests that cancer arises from only certain cells, termed cancer stem cells, contained within the prostate. In this chapter we will discuss in depth the prostate cancer stem cell. We detail the properties of both normal prostate stem cells and cancer stem cells and discuss the identification and isolation of the prostate cancer stem cells, including the current knowledge of the surface markers used for identification. Furthermore, we discuss the signaling pathways that are important in stem cell maintenance and comment on what is known about these pathways in prostate cancer stem cells and how these pathways, and others, may be targeted to inhibit or kill the tumor-initiating cancer stem cells. In conclusion, we provide a short discussion on the future directions for study of prostate cancer stem cells.


Prostate Cancer Cancer Stem Cell Notch Signaling Androgen Deprivation Therapy Side Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This publication has been funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, under contract No. N01-CO-12400. This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Elaine M. Hurt
    • 1
  • George J. Klarmann
    • 2
  • Brian T. Kawasaki
    • 3
  • Nima Sharifi
    • 4
  • William L. Farrar
    • 5
  1. 1.Laboratory of Cancer PreventionNCI-FrederickFrederickUSA
  2. 2.Basic Research ProgramSAIC-Frederick, Inc., NCI-FrederickFrederickUSA
  3. 3.Cancer Stem Cell Section, Laboratory of Cancer PreventionCenter for Cancer Research, National Cancer Institute at Frederick, National Institutes of HealthFrederickUSA
  4. 4.Division of Hematology/OncologyUniversity of Texas Southwestern Medical CenterDallasUSA
  5. 5.Laboratory of Cancer PreventionNCI-FrederickFrederickUSA

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