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Stem Cells and Cancer pp 137–165Cite as

Prostate Cancer Stem Cells

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Abstract

Prostate cancer is the leading cancer diagnosed in males. Emerging data suggests that cancer arises from only certain cells, termed cancer stem cells, contained within the prostate. In this chapter we will discuss in depth the prostate cancer stem cell. We detail the properties of both normal prostate stem cells and cancer stem cells and discuss the identification and isolation of the prostate cancer stem cells, including the current knowledge of the surface markers used for identification. Furthermore, we discuss the signaling pathways that are important in stem cell maintenance and comment on what is known about these pathways in prostate cancer stem cells and how these pathways, and others, may be targeted to inhibit or kill the tumor-initiating cancer stem cells. In conclusion, we provide a short discussion on the future directions for study of prostate cancer stem cells.

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Notes

  1. 1.

    The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

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Acknowledgments

This publication has been funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, under contract No. N01-CO-12400. This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute.

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Authors and Affiliations

  1. Laboratory of Cancer Prevention, NCI-Frederick, 1050 Boyles Street, Building 560, Room 21-81, Frederick, MD 21702, USA

    Elaine M. Hurt

  2. Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA

    George J. Klarmann

  3. Cancer Stem Cell Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA

    Brian T. Kawasaki

  4. Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

    Nima Sharifi

  5. Laboratory of Cancer Prevention, NCI-Frederick, Frederick, Maryland, USA

    William L. Farrar

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  1. Elaine M. Hurt
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    Hurt, E.M., Klarmann, G.J., Kawasaki, B.T., Sharifi, N., Farrar, W.L. (2009). Prostate Cancer Stem Cells. In: Majumder, S. (eds) Stem Cells and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-89611-3_6

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