Cancer Stem Cells and Metastasis: Emerging Themes and Therapeutic Implications

  • Leah Owens
  • Benjamin Tiede
  • Yibin Kang


Recent work in the field of cancer research has provided mounting evidence for the role of cancer stem cells in the establishment of many types of tumors. Insights into intrinsic properties of cancer stem cells are especially important in the context of tumor invasion and metastasis. Although more research is still necessary to solidify the role of cancer stem cells in the initiation of metastatic growth, the multistep cascade of tumor growth and progression as it is currently understood encompasses events likely to involve cancer stem cells and the microenvironment that supports them. This chapter will focus on the perceived roles of cancer stem cells in known tumorigenic and metastatic events. Emerging and evolving models of cancer stem cell-mediated tumor progression provide potential windows of opportunity for developing novel therapeutic strategies aiming at thwarting the menacing power of metastatic cancer stem cells.


Stem Cell Vascular Endothelial Growth Factor Cancer Stem Cell Adult Stem Cell Stem Cell Niche 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Molecular BiologyPrinceton UniversityPrincetonUSA

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