Molecular Regulation of the State of Embryonic Stem Cells

  • Yuko Fujiwara
  • Stuart H. Orkin


Pluripotency is a defining feature of embryonic stem cells (ESCs). A mechanistic understanding of pluripotency should shed light on fundamental aspects of development. In this chapter, we review the extrinsic factors, protein, and gene regulatory networks and epigenetics of ESCs. With the availability of human ESCs and the capacity to reprogram somatic cells to a pluripotent state, we hope that a comprehensive description of the control of pluripotency in ESCs will contribute to the use of these cells in regenerative medicine.


Inner Cell Mass Oct4 Expression Pluripotent State SOX2 Protein Nanog Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Children’s Hospital, Division of Hematology/OncologyHarvard Medical School/Howard Hughes Medical InstituteBostonUSA
  2. 2.Department of Pediatric Oncology, Children’s Hospital BostonDana Faber Cancer Institute, Harvard Medical School, Howard Hughes Medical InstituteBostonUSA

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