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Biomechanics and Pathophysiology of Concussion

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Pediatric and Adolescent Concussion

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Abstract

Major progress in the basic and clinical science of concussion has been realized over the past decade. Innovative new paradigms for brain injury research have advanced our scientific understanding of the biomechanics, true natural history of clinical recovery, and window of cerebral vulnerability associated with concussion. Modern technologies have provided a translational bridge from animal brain injury models to direct study of the characteristics and pathophysiology of concussion in humans. In the overwhelming majority of cases, clinical recovery occurs over a period of several days to weeks after concussion, without persistent symptoms or functional impairments. Young, developing brains may be at heightened risk of serious or catastrophic outcomes following concussion, which are extremely rare. The collective body of research in recent years ultimately provides a more evidence-driven approach to clinical management of concussion in all settings.

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Authors and Affiliations

  1. Departments of Neurosurgery and Neurology, Medical College of Wisconsin, Milwaukee, WI, USA

    Michael McCrea

  2. Neuropsychology Department, Minocqua Behavioral Health, Marshfield Clinic, Minocqua, WI, USA

    Mathew R. Powell

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  1. Michael McCrea
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Correspondence to Michael McCrea .

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Editors and Affiliations

  1. Dept. Psychiatry & Behavioral Medicine, Department of Psychiatry and Behavioral, Medical College of Wisconsin, N 118th Street 2544, Wauwatosa, 53226, Wisconsin, USA

    Jennifer Niskala Apps

  2. Children’s Hospital of Wisconsin, Departments of Orthopaedics & Pediatrics, Medical College of Wisconsin, 9000 W. Wisconsin Avenue Suite C360, Milwaukee, 53201, Wisconsin, USA

    Kevin D. Walter

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McCrea, M., Powell, M.R. (2012). Biomechanics and Pathophysiology of Concussion. In: Apps, J., Walter, K. (eds) Pediatric and Adolescent Concussion. Springer, New York, NY. https://doi.org/10.1007/978-0-387-89545-1_4

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