Phase II: The ICU Phase of Damage Control: Managing the Patient from Door to Door

  • Bryan A. Cotton
  • C. William Schwab

The Intensive Care Unit (ICU) phase has been central to the concept of delayed definitive care of trauma since it was described by Stone and colleagues and later systematically defined and named by Rotondo, Schwab, and colleagues [1, 2]. The initial operative procedures are abbreviated, and temporizing measures are employed, allowing transport to the ICU for correction of metabolic and physiologic problems. When the patient is to return to the operating room for definitive surgical procedures (Phase III) is determined by the success of this phase (Phase II) of care. In addition, careful ICU management can be the difference between prompt fascial closure and rapid liberation from the ventilator and an “unclose-able” abdomen with prolonged mechanical ventilation [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13].


Acute Lung Injury Abdominal Compartment Syndrome Damage Control Open Abdomen Fascial Closure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Rotondo MF, Schwab CW, McGonigal MD, Phillips GR 3rd, Fruchterman TM, Kauder DR, Latenser BA, Angood PA. “Damage control”: an approach for improved survival in exsanguinating penetrating abdominal injury. J Trauma 1993;35(3):375–82.PubMedCrossRefGoogle Scholar
  2. 2.
    Stone HH, Strom PR, Mullins RJ. Management of the major coagulopathy with onset during laparotomy. Ann Surg 1983;197(5):532–5.PubMedCrossRefGoogle Scholar
  3. 3.
    Asensio JA, Petrone P, O’Shanahan G, Kuncir EJ. Managing exsanguination: what we know about damage control/bailout is not enough. Proc (Bayl Univ Med Cent) 2003;16(3):294–6.Google Scholar
  4. 4.
    Balogh Z, McKinley BA, Holcomb JB, Miller CC, Cocanour CS, Kozar RA, Valdivia A, Ware DN, Moore FA. Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of multiple organ failure. J Trauma 2003;54(5):848–59.PubMedCrossRefGoogle Scholar
  5. 5.
    Boldt J, Heesen M, Welters I, Padberg W, Martin K, Hempelmann G. Does the type of volume therapy influence endothelial-related coagulation in the critically ill? Br J Anaesth 1995;75(6):740–6.PubMedGoogle Scholar
  6. 6.
    Burch JM, Ortiz VB, Richardson RJ, Martin RR, Mattox KL, Jordan GL, Jr. Abbreviated laparotomy and planned reoperation for critically injured patients. Ann Surg 1992;215(5):476–83.PubMedCrossRefGoogle Scholar
  7. 7.
    Cotton BA, Guy JS, Morris JA, Jr., Abumrad NN. The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock 2006;26(2):115–21.PubMedCrossRefGoogle Scholar
  8. 8.
    Eddy VA, Morris JA, Jr., Cullinane DC. Hypothermia, coagulopathy, and acidosis. Surg Clin North Am 2000;80(3):845–54.PubMedCrossRefGoogle Scholar
  9. 9.
    Gonzalez EA, Moore FA, Holcomb JB, Miller CC, Kozar RA, Todd SR, Cocanour CS, Balldin BC, McKinley BA. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma 2007;62(1):112–9.PubMedCrossRefGoogle Scholar
  10. 10.
    Gruen RL, Jurkovich GJ, McIntyre LK, Foy HM, Maier RV. Patterns of errors contributing to trauma mortality: lessons learned from 2,594 deaths. Ann Surg 2006;244(3):371–80.PubMedGoogle Scholar
  11. 11.
    McKinley BA, Valdivia A, Moore FA. Goal-oriented shock resuscitation for major torso trauma: what are we learning? Curr Opin Crit Care 2003;9(4):292–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Moore EE, Burch JM, Franciose RJ, Offner PJ, Biffl WL. Staged physiologic restoration and damage control surgery. World J Surg 1998;22(12):1184–90.PubMedCrossRefGoogle Scholar
  13. 13.
    Raeburn CD, Moore EE, Biffl WL, Johnson JL, Meldrum DR, Offner PJ, Franciose RJ, Burch JM. The abdominal compartment syndrome is a morbid complication of postinjury damage control surgery. Am J Surg 2001;182(6):542–6.PubMedCrossRefGoogle Scholar
  14. 14.
    Van Eaton EG, Horvath KD, Lober WB, Pellegrini CA. Organizing the transfer of patient care information: the development of a computerized resident sign-out system. Surgery 2004;136(1):5–13.PubMedCrossRefGoogle Scholar
  15. 15.
    Rohrich RJ, Persing JA, Phillips L. Mandating shorter work hours and enhancing patient safety: a new challenge for resident education. Plast Reconstr Surg 2003;111(1):395–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Grogan EL, Stiles RA, France DJ, Speroff T , Morris Jr J, Nixon B, Gaffney F, Seddon R, Pinson C. The impact of aviation-based teamwork training on the attitudes of health-care professionals. J Am Coll Surg 2004;199(6):843–8.PubMedCrossRefGoogle Scholar
  17. 17.
    Hoff WS, Sicoutris CP, Lee SY, Rotondo MF, Reilly PM, Schwab CW. Formalized radiology rounds: the final component of the tertiary survey. J Trauma 2004;56(2):291–5.PubMedCrossRefGoogle Scholar
  18. 18.
    Van Eaton EG, Horvath KD, Lober WB, Rossini AJ, Pellegrini CA. A randomized, controlled trial evaluating the impact of a computerized rounding and sign-out system on continuity of care and resident work hours. J Am Coll Surg 2005;200(4):538–45.PubMedCrossRefGoogle Scholar
  19. 19.
    Williams RG, Silverman R, Schwind C, Fortune JB, Sutyak J, Horvath KD, Van Eaton EG, Azzie G, Potts III JR, Boehler M, Dunnington GL. Surgeon information transfer and communication: factors affecting quality and efficiency of inpatient care. Ann Surg 2007;245(2):159–69.Google Scholar
  20. 20.
    Ho AM, Karmakar MK, Dion PW. Are we giving enough coagulation factors during major trauma resuscitation? Am J Surg 2005;190(3):479–84.PubMedCrossRefGoogle Scholar
  21. 21.
    Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg 2007;245(5):812–8.PubMedCrossRefGoogle Scholar
  22. 22.
    Hoffman M. The cellular basis of traumatic bleeding. Mil Med 2004;169(12 Suppl):5–7, 4.Google Scholar
  23. 23.
    Cotton BA, Guy JS, Morris JA, Jr., Abumrad NN. The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock 2006;26(2):115–21.PubMedCrossRefGoogle Scholar
  24. 24.
    Farkash U, Lynn M, Scope A et al. Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties? Injury 2002;33(2):103–10.PubMedCrossRefGoogle Scholar
  25. 25.
    Gentilello LM, Moujaes S. Treatment of hypothermia in trauma victims: thermodynamic considerations. J Intensive Care Med 1995;10(1):5–14.PubMedGoogle Scholar
  26. 26.
    Gentilello LM, Jurkovich GJ, Stark MS, Hassantash SA, O’Keefe GE. Is hypothermia in the victim of major trauma protective or harmful? A randomized, prospective study. Ann Surg 1997;226(4):439–47.PubMedCrossRefGoogle Scholar
  27. 27.
    Gubler KD, Gentilello LM, Hassantash SA, Maier RV. The impact of hypothermia on dilutional coagulopathy. J Trauma 1994;36(6):847–51.PubMedCrossRefGoogle Scholar
  28. 28.
    Hardy JF, de Moerloose P, Samama M. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth 2004;51(4):293–310.PubMedCrossRefGoogle Scholar
  29. 29.
    Danks RR. Triangle of death. How hypothermia acidosis and coagulopathy can adversely impact trauma patients. JEMS 2002;27(5):61–70.Google Scholar
  30. 30.
    Ho AM, Dion PW, Cheng CA, Karmakar MK, Cheng G, Peng Ng YW A mathematical model for fresh frozen plasma transfusion strategies during major trauma resuscitation with ongoing hemorrhage. Can J Surg 2005;48(6):470–8.PubMedGoogle Scholar
  31. 31.
    Kearney TJ, Bentt L, Grode M, Lee S, Hiatt JR, Shabot MM. Coagulopathy and catecholamines in severe head injury. J Trauma 1992;32(5):608–11.PubMedCrossRefGoogle Scholar
  32. 32.
    Meng ZH, Wolberg AS, Monroe DM, III, Hoffman M. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma 2003;55(5):886–91.PubMedCrossRefGoogle Scholar
  33. 33.
    Barak M, Rudin M, Vofsi O, Droyan A, Katz Y. Fluid administration during abdominal surgery influences on coagulation in the postoperative period. Curr Surg 2004;61(5):459–62.PubMedCrossRefGoogle Scholar
  34. 34.
    Boldt J, Heesen M, Welters I, Padberg W, Martin K, Hempelmann G. Does the type of volume therapy influence endothelial-related coagulation in the critically ill? Br J Anaesth 1995;75(6):740–6.PubMedGoogle Scholar
  35. 35.
    Ng KF, Lam CC, Chan LC. In vivo effect of haemodilution with saline on coagulation: a randomized controlled trial. Br J Anaesth 2002;88(4):475–80.PubMedCrossRefGoogle Scholar
  36. 36.
    Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris JA Jr, St Jacques P, Young PP. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma 2008;64(5):1177–82.PubMedCrossRefGoogle Scholar
  37. 37.
    Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox E D, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma 2007;62(2):307–10.Google Scholar
  38. 38.
    Clark AD, Gordon WC, Walker ID, Tait RC. “Last-ditch” use of recombinant factor VIIa in patients with massive haemorrhage is ineffective. Vox Sang 2004;86(2):120–4.PubMedCrossRefGoogle Scholar
  39. 39.
    Gowers CJ, Parr MJ. Recombinant activated factor VIIa use in massive transfusion and coagulopathy unresponsive to conventional therapy. Anaesth Intensive Care 2005;33(2):196–200.PubMedGoogle Scholar
  40. 40.
    Hedner U, Erhardtsen E. Potential role of recombinant factor VIIa as a hemostatic agent. Clin Adv Hematol Oncol 2003;1(2):112–9.PubMedGoogle Scholar
  41. 41.
    Holcomb JB. Use of recombinant activated factor VII to treat the acquired coagulopathy of trauma. J Trauma 2005;58(6):1298–303.PubMedCrossRefGoogle Scholar
  42. 42.
    Holcomb JB, Hoots K, Moore FA. Treatment of an acquired coagulopathy with recombinant activated factor VII in a damage-control patient. Mil Med 2005;170(4):287–90.PubMedGoogle Scholar
  43. 43.
    Sagraves SG, Toschlog EA, Rotondo MF. Damage control surgery – the intensivist’s role. J Intensive Care Med 2006;21(1):5–16.PubMedCrossRefGoogle Scholar
  44. 44.
    Engstrom M, Schott U, Romner B, Reinstrup P. Acidosis impairs the coagulation: a thromboelastographic study. J Trauma 2006;61(3):624–8.PubMedCrossRefGoogle Scholar
  45. 45.
    Moomey CB, Jr., Melton SM, Croce MA, Fabian TC, Proctor KG. Prognostic value of blood lactate, base deficit, and oxygen-derived variables in an LD50 model of penetrating trauma. Crit Care Med 1999;27(1):154–61.PubMedCrossRefGoogle Scholar
  46. 46.
    Abramson D, Scalea TM, Hitchcock R, Trooskin SZ, Henry SM, Greenspan J. Lactate clearance and survival following injury. J Trauma 1993;35(4):584–8.PubMedCrossRefGoogle Scholar
  47. 47.
    Martin MJ, FitzSullivan E, Salim A, Brown CV, Demetriades D, Long W. Discordance between lactate and base deficit in the surgical intensive care unit: which one do you trust? Am J Surg 2006;191(5):625–30.PubMedCrossRefGoogle Scholar
  48. 48.
    FitzSullivan E, Salim A, Demetriades D, Asensio J, Martin MJ. Serum bicarbonate may replace the arterial base deficit in the trauma intensive care unit. Am J Surg 2005;190(6):941–6.PubMedCrossRefGoogle Scholar
  49. 49.
    Gunnerson KJ, Kellum JA. Acid-base and electrolyte analysis in critically ill patients: are we ready for the new millennium? Curr Opin Crit Care 2003;9(6):468–73.PubMedCrossRefGoogle Scholar
  50. 50.
    Holmdahl MH, Wiklund L, Wetterberg T, Streat S, Wahlander S, Sutin K, Nahas G. The place of THAM in the management of acidemia in clinical practice. Acta Anaesthesiol Scand 2000;44(5):524–7.PubMedCrossRefGoogle Scholar
  51. 51.
    Nahas GG, Sutin KM, Fermon C, Streat S, Wiklund L. Guidelines for the treatment of acidaemia with THAM. Drugs 1998;55(2):191–224.PubMedCrossRefGoogle Scholar
  52. 52.
    Gentilello LM, Jurkovich GJ, Stark MS, Hassantash SA, O’Keefe GE. Is hypothermia in the victim of major trauma protective or harmful? A randomized, prospective study. Ann Surg 1997;226(4):439–47.PubMedCrossRefGoogle Scholar
  53. 53.
    Arthurs Z, Cuadrado D, Beekley A, Grathwohl K, Perkins J, Rush R, Sebesta J. The impact of hypothermia on trauma care at the 31st combat support hospital. Am J Surg 2006;191(5):610–4.PubMedCrossRefGoogle Scholar
  54. 54.
    Ferrara A, MacArthur JD, Wright HK, Modlin IM, McMillen MA. Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion. Am J Surg 1990;160(5):515–8.PubMedCrossRefGoogle Scholar
  55. 55.
    Hildebrand F, van GM, Giannoudis P, Schreiber T, Frink M, Probst C, Grotz M, Krettek C, Pape HC. Impact of hypothermia on the immunologic response after trauma and elective surgery. Surg Technol Int 2005;14:41–50.Google Scholar
  56. 56.
    Gentilello LM, Moujaes S. Treatment of hypothermia in trauma victims: thermodynamic considerations. J Intensive Care Med 1995;10(1):5–14.PubMedGoogle Scholar
  57. 57.
    Patel N, Smith CE, Pinchak AC. Comparison of fluid warmer performance during simulated clinical conditions. Can J Anaesth 1995;42(7):636–42.PubMedCrossRefGoogle Scholar
  58. 58.
    Patel N, Knapke DM, Smith CE, Napora TE, Pinchak AC, Hagen JF. Simulated clinical evaluation of conventional and newer fluid-warming devices. Anesth Analg 1996;82(3):517–24.PubMedCrossRefGoogle Scholar
  59. 59.
    Smith CE, Desai R, Glorioso V, Cooper A, Pinchak AC, Hagen KF. Preventing hypothermia: convective and intravenous fluid warming versus convective warming alone. J Clin Anesth 1998;10(5):380–5.PubMedCrossRefGoogle Scholar
  60. 60.
    Smith CE, Parand A, Pinchak AC, Hagen JF, Hancock DE. The failure of negative pressure rewarming (Thermostat) to accelerate recovery from mild hypothermia in postoperative surgical patients. Anesth Analg 1999;89(6):1541–5.PubMedCrossRefGoogle Scholar
  61. 61.
    Danzl D. Hypothermia. Semin Respir Crit Care Med 2002;23(1):57–68.PubMedCrossRefGoogle Scholar
  62. 62.
    Garraway N, Brown DR, Nash D, Kirkpatrick A, Schneidereit N, Van Heest R, Hwang H, Simons R. Active internal re-warming using a centrifugal pump and heat exchanger following haemorrhagic shock, surgical trauma and hypothermia in a porcine model. Injury 2007;38(9):1039–46.PubMedCrossRefGoogle Scholar
  63. 63.
    Gentilello LM, Rifley WJ. Continuous arteriovenous rewarming: report of a new technique for treating hypothermia. J Trauma 1991;31(8):1151–4.PubMedGoogle Scholar
  64. 64.
    Gentilello LM. Advances in the management of hypothermia. Surg Clin North Am 1995;75(2):243–56.PubMedGoogle Scholar
  65. 65.
    Jurkovich GJ, Greiser WB, Luterman A, Curreri PW. Hypothermia in trauma victims: an ominous predictor of survival. J Trauma 1987;27(9):1019–24.PubMedCrossRefGoogle Scholar
  66. 66.
    Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, Chalfin DB, Masica MR, Bjerke HS, Coplin WM, Crippen DW, Fuchs BD, Kelleher RM, Marik PE, Nasraway Jr SA, Murray MJ, Peruzzi WT, Lumb PD. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002;30(1):119–41.PubMedCrossRefGoogle Scholar
  67. 67.
    Payen JF, Bru O, Bosson JL, Lagrasta A, Novel E, Deschaux I, Lavagne P, Jacquot C. Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med 2001;29(12):2258–63.PubMedCrossRefGoogle Scholar
  68. 68.
    Ely EW, Truman B, Shintani A, Thomason JWW, Wheeler AP, Gordon S, Francis J, Speroff T, Gautam S, Margolin R, Sessler CN, Dittus RS, Bernard GR. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA 2003;289(22):2983–91.PubMedCrossRefGoogle Scholar
  69. 69.
    Chisholm CJ, Zurica J, Mironov D, Sciacca RR, Ornstein E, Heyer EJ. Comparison of electrophysiologic monitors with clinical assessment of level of sedation. Mayo Clin Proc 2006;81(1):46–52.PubMedCrossRefGoogle Scholar
  70. 70.
    Sackey PV, Radell PJ, Granath F, Martling CR. Bispectral index as a predictor of sedation depth during isoflurane or midazolam sedation in ICU patients. Anaesth Intensive Care 2007;35(3):348–56.PubMedGoogle Scholar
  71. 71.
    Hall RI, Sandham D, Cardinal P, Tweeddale M, Moher D, Wang X, Anis AS, for the Study Investigators. Propofol vs midazolam for ICU sedation: a Canadian multicenter randomized trial. Chest 2001;119(4):1151–9.Google Scholar
  72. 72.
    Maze M, Scarfini C, Cavaliere F. New agents for sedation in the intensive care unit. Crit Care Clin 2001;17(4):881–97.PubMedCrossRefGoogle Scholar
  73. 73.
    Venn RM, Grounds RM. Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. Br J Anaesth 2001;87(5):684–90.PubMedCrossRefGoogle Scholar
  74. 74.
    Venn RM, Karol MD, Grounds RM. Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive caret. Br J Anaesth 2002;88(5):669–75.PubMedCrossRefGoogle Scholar
  75. 75.
    Duff JF, Moffat J. Abdominal sepsis managed by leaving the abdomen open. Surgery 1981;90:774–778.Google Scholar
  76. 76.
    De Waele JJ, De Iaet I, Malbrain ML. Intraabdominal hypertension and abdominal compartment syndrome: we have paid attention, now it is time to understand! Acta Clin Belg Suppl 2007;(1):6–8.Google Scholar
  77. 77.
    De Iaet I, Hoste E, Verholen E, De Waele JJ. The effect of neuromuscular blockers in patients with intra-abdominal hypertension. Intensive Care Med 2007;33(10):1811–4.CrossRefGoogle Scholar
  78. 78.
    Malbrain ML, De Iaet I, Cheatham M. Consensus conference definitions and recommendations on intra-abdominal hypertension (IAH) and the abdominal compartment syndrome (ACS) – the long road to the final publications, how did we get there? Acta Clin Belg Suppl 2007;(1):44–59.Google Scholar
  79. 79.
    Cereda M, Weiss YG, Deutschman CS. The critically ill injured patient. Anesthesiol Clin 2007;25(1):13–21, vii.Google Scholar
  80. 80.
    Spinella PC, Priestley MA. Damage control mechanical ventilation: ventilator induced lung injury and lung protective strategies in children. J Trauma 2007;62(6 Suppl):S82–3.PubMedCrossRefGoogle Scholar
  81. 81.
    Plurad D, Martin M, Green D, Salim A, Inaba K, Belzberg H, Demetriades D, Rhee P. The decreasing incidence of late posttraumatic acute respiratory distress syndrome: the potential role of lung protective ventilation and conservative transfusion practice. J Trauma 2007;63(1):1–7.PubMedCrossRefGoogle Scholar
  82. 82.
    Martin GS, Mangialardi RJ, Wheeler AP, Dupont WD, Morris JA, Bernard GR. Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit Care Med 2002;30(10):2175–82.PubMedCrossRefGoogle Scholar
  83. 83.
    Putensen C. Volume-controlled versus biphasic positive airway pressure. Crit Care Med 1997;25(1):203–5.PubMedCrossRefGoogle Scholar
  84. 84.
    Putensen C, Mutz NJ, Putensen-Himmer G, Zinserling J. Spontaneous breathing during ventilatory support improves ventilation-perfusion distributions in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 1999;159(4 Pt 1):1241–8.PubMedGoogle Scholar
  85. 85.
    The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000;342(18):1301–8.Google Scholar
  86. 86.
    Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med 2007;35(10):2243–50.Google Scholar
  87. 87.
    Eisner MD, Thompson T, Hudson LD, Luce JM, Hayden D, Schoenfeld D, Matthay MA, the Acute Respiratory Distress Syndrome Network. Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;164(2):231–6.Google Scholar
  88. 88.
    Eisner MD, Thompson BT, Schoenfeld D, Anzueto A, Matthay MA. Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome. Am J Respir Crit Care Med 2002;165(7):978–82.PubMedGoogle Scholar
  89. 89.
    Gajic O, Dara SI, Mendez JL, Adesanya AO, Festic E, Caples SM, Rana R, St. Sauver JL, Lymp JF, Afessa B, Hubmayr RD. Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit Care Med 2004;32(9):1817–24.Google Scholar
  90. 90.
    Wolthuis EK, Choi G, Dessing MC, Bresser PM, Lutter R, Dzoljic M, van der Poll T, Vroom MB, Hollmann M, Schultz MJ. Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology 2008;108(1):46–54.PubMedCrossRefGoogle Scholar
  91. 91.
    Chu EK, Whitehead T, Slutsky AS. Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines. Crit Care Med 2004;32(1):168–74.PubMedCrossRefGoogle Scholar
  92. 92.
    Grasso S, Mascia L, Del TM, Del Turco M, Malacarne P, Giunta F, Brochard L, Slutsky AS, Marco Ranieri, V. Effects of recruiting maneuvers in patients with acute respiratory distress syndrome ventilated with protective ventilatory strategy. Anesthesiology 2002;96(4):795–802.Google Scholar
  93. 93.
    Friese RS, Shafi S, Gentilello LM. Pulmonary artery catheter use is associated with reduced mortality in severely injured patients: a National Trauma Data Bank analysis of 53,312 patients. Crit Care Med 2006;34(6):1597–601.PubMedCrossRefGoogle Scholar
  94. 94.
    Chang MC, Black CS, Meredith JW. Volumetric assessment of preload in trauma patients: addressing the problem of mathematical coupling. Shock 1996;6(5):326–9.PubMedCrossRefGoogle Scholar
  95. 95.
    Friese RS, Dineen S, Jennings A, Pruitt J, McBride D, Shafi S, Frankel H, Gentilello LM. Serum B-type natriuretic peptide: a marker of fluid resuscitation after injury? J Trauma 2007;62(6):1346–50.PubMedCrossRefGoogle Scholar
  96. 96.
    Hannemann L, Reinhart K, Grenzer O, Meier-Hellmann A, Bredle DL. Comparison of dopamine to dobutamine and norepinephrine for oxygen delivery and uptake in septic shock. Crit Care Med 1995;23(12):1962–70.PubMedCrossRefGoogle Scholar
  97. 97.
    Hsu TC, Su CF, Leu SC, Huang PC, Wang TE, Chu CH. Omeprazole is more effective than a histamine H2-receptor blocker for maintaining a persistent elevation of gastric pH after colon resection for cancer. Am J Surg 2004;187(1):20–3.PubMedCrossRefGoogle Scholar
  98. 98.
    Lasky MR, Metzler MH, Phillips JO. A prospective study of omeprazole suspension to prevent clinically significant gastrointestinal bleeding from stress ulcers in mechanically ventilated trauma patients. J Trauma 1998;44(3):527–33.PubMedCrossRefGoogle Scholar
  99. 99.
    Phillips JO, Metzler MH, Palmieri MT, Huckfeldt RE, Dahl NG. A prospective study of simplified omeprazole suspension for the prophylaxis of stress-related mucosal damage. Crit Care Med 1996;24(11):1793–800.PubMedCrossRefGoogle Scholar
  100. 100.
    Cook D, Guyatt G, Marshall J, Leasa D, Fuller H, Hall R, Peters S, Rutledge F, Griffith L, McLellan A, Wood G, Kirby A, Tweeddale M, Pagliarello Johnston J, The Canadian Critical Care Trials Group. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. N Engl J Med 1998;338(12):791–7.Google Scholar
  101. 101.
    Cook DJ, Fuller HD, Guyatt GH, Marshall JC, Leasa D, Hall R, Winton TL, Rutledge F, Todd T, Roy P, Lacroix J, Griffith L, Willan A, The Canadian Critical Care Trials Group. Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med 1994;330(6):377–81.Google Scholar
  102. 102.
    Kudsk KA, Croce MA, Fabian TC, Minard G, Tolley EA, Poret HA, Kuhl MR, Brown RO. Enteral versus parenteral feeding. Effects on septic morbidity after blunt and penetrating abdominal trauma. Ann Surg 1992;215(5):503–11.Google Scholar
  103. 103.
    Marik PE, Zaloga GP. Early enteral nutrition in acutely ill patients: a systematic review. Crit Care Med 2001;29(12):2264–70.PubMedCrossRefGoogle Scholar
  104. 104.
    Moore EE, Dunn EL, Jones TN. Immediate jejunostomy feeding. Its use after major abdominal trauma. Arch Surg 1981;116(5):681–4.Google Scholar
  105. 105.
    Moore EE, Jones TN. Benefits of immediate jejunostomy feeding after major abdominal trauma – a prospective, randomized study. J Trauma 1986;26(10):874–81.PubMedCrossRefGoogle Scholar
  106. 106.
    Moore FA, Feliciano DV, Andrassy RJ et al. Early enteral feeding, compared with parenteral, reduces postoperative septic complications. The results of a meta-analysis. Ann Surg 1992;216(2):172–83.Google Scholar
  107. 107.
    Scaife CL, Saffle JR, Morris SE. Intestinal obstruction secondary to enteral feedings in burn trauma patients. J Trauma 1999;47(5):859–63.PubMedCrossRefGoogle Scholar
  108. 108.
    Schunn CD, Daly JM. Small bowel necrosis associated with postoperative jejunal tube feeding. J Am Coll Surg 1995;180(4):410–6.PubMedGoogle Scholar
  109. 109.
    Revelly JP, Tappy L, Berger MM, Gersbach P, Cayeux C, Chiolero R. Early metabolic and splanchnic responses to enteral nutrition in postoperative cardiac surgery patients with circulatory compromise. Intensive Care Med 2001;27(3):540–7.PubMedCrossRefGoogle Scholar
  110. 110.
    Zaloga GP, Black KW, Prielipp R. Effect of rate of enteral nutrient supply on gut mass. JPEN J Parenter Enteral Nutr 1992;16(1):39–42.PubMedCrossRefGoogle Scholar
  111. 111.
    Zaloga GP, Roberts P. Permissive underfeeding. New Horiz 1994;2(2):257–63.PubMedGoogle Scholar
  112. 112.
    Krishnan JA, Parce PB, Martinez A, Diette GB, Brower RG. Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes. Chest 2003;124(1):297–305.PubMedCrossRefGoogle Scholar
  113. 113.
    Rubinson L, Diette GB, Song X, Brower RG, Krishnan JA. Low caloric intake is associated with nosocomial bloodstream infections in patients in the medical intensive care unit. Crit Care Med 2004;32(2):350–7.PubMedCrossRefGoogle Scholar
  114. 114.
    Collier B, Guillamondegui O, Cotton B, Donahue R, Conrad A, Groh K, Richman J, Vogel T, Miller R, Diaz Jr J. Feeding the open abdomen. JPEN J Parenter Enteral Nutr 2007;31(5):410–5.PubMedCrossRefGoogle Scholar
  115. 115.
    Cheatham ML, Safcsak K, Brzezinski SJ, Lube MW. Nitrogen balance, protein loss, and the open abdomen. Crit Care Med 2007;35(1):127–31.PubMedCrossRefGoogle Scholar
  116. 116.
    Radhakrishnan RS, Xue H, Moore-Olufemi SD, Weisbrodt NW, Moore FA, Allen SJ, Laine GA, Cox Jr CS. Hypertonic saline resuscitation prevents hydrostatically induced intestinal edema and ileus. Crit Care Med 2006;34(6):1713–8.PubMedCrossRefGoogle Scholar
  117. 117.
    Vassar MJ, Fischer RP, O’Brien PE, Bachulis BL, Chambers JA, Hoyt DB, Holcroft JW. A multicenter trial for resuscitation of injured patients with 7.5% sodium chloride. The effect of added dextran 70. The Multicenter Group for the Study of Hypertonic Saline in Trauma Patients. Arch Surg 1993;128(9):1003–11.Google Scholar
  118. 118.
    Hess JR, Holcomb JB, Hoyt DB. Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma. Transfusion 2006;46(5):685–6.PubMedCrossRefGoogle Scholar
  119. 119.
    Madigan MC, Kemp CD, Johnson JC, Cotton BA. Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame? J Trauma 2008;64(2):280–5.PubMedCrossRefGoogle Scholar
  120. 120.
    Merten GJ, Burgess WP, Gray LV, Holleman JH, Roush TS,. Kowalchuk GJ, Bersin RM, Van Moore A, Simonton III CA, Rittase RA, Norton HJ, Kennedy TP. Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. JAMA 2004;291(19):2328–34.Google Scholar
  121. 121.
    Ligtenberg JJ, Girbes AR, Beentjes JA, Tulleken JE, van der Werf TS, Zijlstra JG. Hormones in the critically ill patient: to intervene or not to intervene? Intensive Care Med 2001;27(10):1567–77.PubMedCrossRefGoogle Scholar
  122. 122.
    Annane D, Sebille V, Charpentier C, Bollaert P-E, François B, Korach J-M, Capellier M, Cohen Y, Azoulay E, Troché G, Chaumet-Riffaut P, Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288(7):862–71.PubMedCrossRefGoogle Scholar
  123. 123.
    Van den BG, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345(19):1359–67.CrossRefGoogle Scholar
  124. 124.
    Bochicchio GV, Sung J, Joshi M, Bochicchio K, Johnson SB, Meyer W, Scalea TM. Persistent hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005;58(5):921–4.PubMedCrossRefGoogle Scholar
  125. 125.
    Laird AM, Miller PR, Kilgo PD, Meredith JW, Chang MC. Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 2004;56(5):1058–62.PubMedCrossRefGoogle Scholar
  126. 126.
    Marik PE, Varon J. Intensive insulin therapy in the ICU: is it now time to jump off the bandwagon? Resuscitation 2007;74(1):191–3.PubMedCrossRefGoogle Scholar
  127. 127.
    Cotton BA, Guillamondegui OD, Fleming SB, Carpenter RO, Patel SH, Morris Jr JA, Arbogast PG. Increased risk of adrenal insufficiency following etomidate exposure in critically injured patients. Arch Surg 2008;143(1):62–7.PubMedCrossRefGoogle Scholar
  128. 128.
    Gannon TA, Britt RC, Weireter LJ, Cole FJ, Collins JN, Britt LD. Adrenal insufficiency in the critically III trauma population. Am Surg 2006;72(5):373–6.PubMedGoogle Scholar
  129. 129.
    Fabian TC, Croce MA, Payne LW, Minard G, Pritchard FE, Kudsk KA. Duration of antibiotic therapy for penetrating abdominal trauma: a prospective trial. Surgery 1992;112(4):788–94.PubMedGoogle Scholar
  130. 130.
    Luchette FA, Borzotta AP, Croce MA, O’Neill PA, Whittmann DH, Mullins CD, Palumbo F, Pasquale MD. Practice management guidelines for prophylactic antibiotic use in penetrating abdominal trauma: the EAST Practice Management Guidelines Work Group. J Trauma 2000;48(3):508–18.PubMedCrossRefGoogle Scholar
  131. 131.
    Shatz DV, Romero-Steiner S, Elie CM, Holder PF, Carlone GM. Antibody responses in postsplenectomy trauma patients receiving the 23-valent pneumococcal polysaccharide vaccine at 14 versus 28 days postoperatively. J Trauma 2002;53(6):1037–42.PubMedCrossRefGoogle Scholar
  132. 132.
    Suliburk JW, Ware DN, Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Moore FA. Vacuum-assisted wound closure achieves early fascial closure of open abdomens after severe trauma. J Trauma 2003;55(6):1155–60.Google Scholar
  133. 133.
    Gracias VH, Braslow B, Johnson J, Pryor J, Gupta R, Reilly P, Schwab CW. Abdominal compartment syndrome in the open abdomen. Arch Surg 2002;137(11):1298–300.PubMedCrossRefGoogle Scholar
  134. 134.
    Cheatham ML, Malbrain ML, Kirkpatrick A, Sugrue M, Parr M, De Waele J, Balogh Z, Leppäniemi A, Olvera C, Ivatury R, D’Amours S, Wendon J, Hillman K, Johansson K, Kolkman K, Wilmer A. Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations. Intensive Care Med 2007;33(6):951–62.Google Scholar
  135. 135.
    Malbrain ML, Cheatham ML, Kirkpatrick A, Sugrue M, Parr M, De Waele J, Balogh Z, Leppäniemi A, Olvera C, Ivatury R, D’Amours S, Wendon J, Hillman K, Johansson K, Kolkman K, Wilmer A. Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions. Intensive Care Med 2006;32(11):1722–32.Google Scholar
  136. 136.
    Martin RR, Byrne M. Postoperative care and complications of damage control surgery. Surg Clin North Am 1997;77(4):929–42.PubMedCrossRefGoogle Scholar
  137. 137.
    Hirshberg A, Mattox KL. Planned reoperation for severe trauma. Ann Surg 1995;222(1):3–8.PubMedCrossRefGoogle Scholar
  138. 138.
    Grossman MD, Born C. Tertiary survey of the trauma patient in the intensive care unit. Surg Clin North Am 2000;80(3):805–24.PubMedCrossRefGoogle Scholar
  139. 139.
    Vargo DJ, Battistella FD. Abbreviated thoracotomy and temporary chest closure: an application of damage control after thoracic trauma. Arch Surg 2001;136(1):21–4.PubMedCrossRefGoogle Scholar
  140. 140.
    Phelan HA, Patterson SG, Hassan MO, Gonzalez RP, Rodning CB. Thoracic damage-control operation: principles, techniques, and definitive repair. J Am Coll Surg 2006;203(6):933–41.PubMedCrossRefGoogle Scholar
  141. 141.
    McArthur BJ. Damage control surgery for the patient who has experienced multiple traumatic injuries. AORN J 2006;84(6):992–1000.PubMedCrossRefGoogle Scholar
  142. 142.
    Kaplan LJ, Trooskin SZ, Santora TA. Thoracic compartment syndrome. J Trauma 1996;40(2):291–3.PubMedCrossRefGoogle Scholar
  143. 143.
    Chambers LW, Green DJ, Sample K, Gillingham BL, Rhee P, Brown C, Narine N, Uecker JM, Bohman HR. Tactical surgical intervention with temporary shunting of peripheral vascular trauma sustained during Operation Iraqi Freedom: one unit’s experience. J Trauma 2006;61(4):824–30.PubMedCrossRefGoogle Scholar
  144. 144.
    Sriussadaporn S, Pak-art R. Temporary intravascular shunt in complex extremity vascular injuries. J Trauma 2002;52(6):1129–33.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of SurgeryVanderbilt University School of MedicineNashvilleUSA

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