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Drug Resistance in Malaria in Developing Countries

  • Quique Bassat
  • Pedro L. Alonso
Chapter

Abstract

A combination of complementary strategies is needed to control malaria, the most important parasitic infection causing an enormous burden of disease throughout the world. Antimalarial drugs play a crucial role among such strategies, as they may be used both for the treatment of cases and for their prevention. In the recent years, the treatment of malaria has been hampered by the emergence of widespread drug resistance to many of the available antimalarial drugs. This review attempts to give an insight of the history of malarial treatment and to describe the current status of drug-resistant malaria. The general determinants of drug resistance and the potential confounding factors for treatment failure will be assessed before a more thorough description of the specific mechanisms among host, vector, parasite and environment is summarized. Finally, the most important molecular pathways of drug resistance will be reviewed for each of the main drug families, together with an outline on the current methods for drug resistance diagnosis and surveillance.

Keywords

Drug Resistance Antimalarial Drug Artemisinin Combination Therapy Intermittent Preventive Treatment Drug Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Barcelona Center for International Health Research (CRESIB), Hospital Clínic/Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de BarcelonaBarcelonaSpain
  2. 2.Centro de Investigação em Saúde de Manhiça (CISM)MaputoMozambique

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