Dynamic-Clamp pp 321-345 | Cite as

Using the Dynamic Clamp to Dissect the Properties and Mechanisms of Intrinsic Thalamic Oscillations

  • Stuart W. Hughes
  • Magor Lörincz
  • David W. Cope
  • Vincenzo Crunelli
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI, volume 1)


During different stages of vigilance, the thalamus engages in a range of rhythmic activities from the slow (<1 Hz), delta (δ) (1–4 Hz) and spindle (7–14 Hz) waves that permeate the brain during sleep and anaesthesia to the faster oscillations in the alpha (α) and beta/gamma (β/γ) (>15 Hz) bands that occur during wakefulness. In recent years, it has been shown that several of these oscillations are associated with intrinsic rhythmic activity in individual thalamocortical (TC) neurons, with these intrinsic oscillations also being readily observable in recordings of TC neurons from thalamic slice preparations. In this chapter we will show how the dynamic-clamp technique provides an extremely useful means for studying the intricate cellular mechanisms and key properties of some of theses intrinsic oscillations. We will mainly focus on the intrinsic δ or so-called pacemaker (∼1–2 Hz) oscillation and the slow (<1 Hz) oscillation but will also briefly discuss how the dynamic-clamp technique can be utilized to study additional important oscillatory phenomena in the thalamus.


Slow Oscillation mGluR Agonist Intrinsic Oscillation Dynamic Clamp Leak Ratio 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Our ongoing work is supported by the Wellcome Trust, grants 71436, 78403 and 78311.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Stuart W. Hughes
    • 1
  • Magor Lörincz
  • David W. Cope
  • Vincenzo Crunelli
  1. 1.School of BiosciencesCardiff UniversityUK

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