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Retinoblastoma pp 115-126 | Cite as

Second Malignancies and Other Long Term Effects in Retinoblastoma Survivors

  • C. Rodriguez-Galindo
Chapter
Part of the Pediatric Oncology book series (PEDIATRICO)

Abstract

Retinoblastoma is a cancer in the very young, and patients are very susceptible to the long term effects that the disease and the treatments administered may have in organ development and function. More importantly, patients with bilateral retinoblastoma are born with a germ-line mutation of the RB1 gene, probably the most potent tumor suppressor gene, and are at risk of developing cancers throughout their lives; in this regard, retinoblastoma may be just the beginning.

Keywords

Soft Tissue Sarcoma Cumulative Incidence Malignant Fibrous Histiocytoma Standardize Incidence Ratio Ewing Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Dana-Farber Cancer Institute and Children’s Hospital Harvard Medical SchoolBostonUSA

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