Clinical Features, Diagnosis, Pathology

  • P. Chévez-BarriosEmail author
  • D. S. Gombos
Part of the Pediatric Oncology book series (PEDIATRICO)


This chapter will review the clinical and histopathologic features associated with the presentation and diagnosis of retinoblastoma. A thorough appreciation of the differential and a detailed clinical assessments is the cornerstone of arriving at the proper diagnosis. Unlike most cancers, retinoblastoma is unique, as tissue is generally not necessary for diagnostic and treatment purposes. However, once the eye is enucleated, the histopathologic features guide therapy and prognosis. We will review ancillary testing that can assist the clinician and address pathologic features that can affect patient prognosis.


Optic Nerve Lamina Cribrosa Neovascular Glaucoma Ancillary Testing Choroidal Invasion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PathologyThe Methodist Hospital Weill College of Medicine of Cornell UniversityHoustonUSA
  2. 2.Department of Head and Neck Surgery Section of OphthalmologyThe University of Texas MD. Anderson Cancer CenterHoustonUSA

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