Quantitative Risk Assessment of Bovine Spongiform Encephalopathy

  • Toshiyuki Tsutsui
  • Fumiko Kasuga
Part of the Food Microbiology and Food Safety book series (FMFS)


Bovine spongiform encephalopathy (BSE) is a progressive neurological disease of cattle affecting the central nervous system and was first diagnosed in the United Kingdom (UK) in 1986 (Wells et al., 1987). This disease is one of the transmissible spongiform encephalopathy (TSE) which includes Creutzfeldt–Jakob disease (CJD) in humans and scrapie in sheep. The causative agent of TSE is considered to be an abnormal form of prion protein. However, the details of its pathogenic mechanism have not been fully identified. Scrapie, which causes neurological symptoms in sheep and goats, has existed in the UK for 200 years (Hoinville, 1996) and spread across the rest of the world in the 1900s (Detwiler & Baylis, 2003). There has been no report so far that scrapie can be transmitted to humans. Initially, BSE was also considered as a disease affecting only animals. However, a variant type of Creutzfeldt–Jakob disease (vCJD) was first reported in the UK, and exposure to a BSE agent was...


Risk Assessment Bovine Spongiform Encephalopathy Clinical Onset Risk Assessment Model Infected Cattle 
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  1. Anderson, R. M., Donnelly, C. A., Ferguson, N. M., Woolhouse, M. E., Watt, C. J., Udy, H. J., et al. (1996). Transmission dynamics and epidemiology of BSE in British cattle. Nature, 382, 779–788.CrossRefGoogle Scholar
  2. Arnold, M. A., & Wilesmith, J. (2003). Modelling studies on bovine spongiform encephalopathy occurrence to assist in the review of the over 30 months rule in Great Britain. Philosophical transactions of the Royal Society of London. Series B, Biological Sciences, 270, 2141–2145.Google Scholar
  3. Beekes, M., Baldauf, E., & Diringer, H. (1996). Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie. The Journal of General Virology, 77(Pt. 8), 1925–1934.CrossRefGoogle Scholar
  4. Calavas, D., Supervie, V., Morignat, E., Costagliola, D., & Ducrot, C. (2007). Complementary approach of data analysis and modeling to estimate the pattern of the BSE epidemic: The example of France. Risk analysis, 27, 1141–1150.CrossRefGoogle Scholar
  5. Collinge, J., Sidle, K. C., Meads, J., Ironside, J., & Hill, A.F. (1996). Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature, 383, 685–690.CrossRefGoogle Scholar
  6. Comer P. J., & Huntly P. J. (2003). TSE risk assessments: A decision support tool. Statistical Methods in Medical Research, 12, 279–291.CrossRefGoogle Scholar
  7. Cooper, J. D., & Bird, S. M. (2002). UK dietary exposure to BSE in beef mechanically recovered meat: By birth cohort and gender. Journal of Cancer Epidemiology and Prevention, 7, 59–70.CrossRefGoogle Scholar
  8. de Koeijer, A., Heesterbeek, H., Schreuder, B., Oberthür, R., Wilesmith, J., van Roermund, H., et al. (2004). Quantifying BSE control by calculating the basic reproduction ratio R0 for the infection among cattle. Journal of Mathematical Biology, 48(1), 1–22.CrossRefGoogle Scholar
  9. Detwiler, L. A., & Baylis, M. (2003). The epidemiology of scrapie. Revue Scientifique et Technique, 22, 121–143.Google Scholar
  10. DNV. (1997). Assessment of risk from possible BSE Infectivity in dorsal root ganglia (Report C7831, Rev 1). London: Det Norske Veritas.Google Scholar
  11. Ferguson, N. M., & Donnelly, C. A. (2003). Assessment of the risk posed by bovine spongiform encephalopathy in cattle in Great Britain and the impact of potential changes to current control measures. Philosophical transactions of the Royal Society of London. Series B, Biological Sciences, 270, 1579–1584.Google Scholar
  12. Ferguson N. M., Donnelly C. A., Woolhouse, M. E., & Anderson, R. M. (1997). The epidemiology of BSE in cattle herds in Great Britain. II. Model construction and analysis of transmission dynamics. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 352, 803–838.CrossRefGoogle Scholar
  13. Gale, P., & Stanfield, G. (2001). Towards a quantitative risk assessment for BSE in sewage sludge. Journal of Applied Microbiology, 91, 563–569.CrossRefGoogle Scholar
  14. Ghani, A. C., Ferguson, N. M., Donnelly, C. A., Hagenaars, T. J., & Anderson, R. M. (1998). Estimation of the number of people incubating variant CJD. Lancet, 352, 1353–1354.CrossRefGoogle Scholar
  15. Gravenor, M. B., & Kao, R. R. (2003). Risk assessments on BSE. Veterinary Record, 152(26), 816.Google Scholar
  16. Hoinville, L. J. (1996). A review of the epidemiology of scrapie in sheep. Revue Scientifique et Technique, 15(3)827–852.Google Scholar
  17. OIE (Office International des Epizooties). (2007). International animal health code: Mammals, birds and bees (Chapter 2.3.13). htm
  18. Paisley, L. G., & Hostrup-Pedersen, J. (2004). A quantitative assessment of the risk of transmission of bovine spongiform encephalopathy by tallow-based calf milk-replacer. Preventive Veterinary Medicine, 63(1–2), 135–149.Google Scholar
  19. SSC (Scientific Steering Committee, European Commission). (1999). The evaluation of tests for the diagnosis of transmissible spongiform encephalopathy in bovine. /biosafety /bse/bse12_en.pdf
  20. SSC (Scientific Steering Committee, European Commission). (2002). Update of the opinion on TSE infectivity distribution in ruminant tissues.
  21. Supervie, V., & Costagliola, D. (2007). BSE risk assessment as a basis for updating french screening policy. Risk Analysis, 27(5), 1131–1140.CrossRefGoogle Scholar
  22. Tsutsui, T., & Kasuga, F. (2006). Assessment of the impact of cattle testing strategies on human exposure to BSE agents in Japan. International Journal of Food Microbiology, 107, 256–264.CrossRefGoogle Scholar
  23. Wells, G. A., Konold, T., Arnold, M. E., Austin, A. R., Hawkins, S. A., Stack, M., et al. (2007). Bovine spongiform encephalopathy: The effect of oral exposure dose on attack rate and incubation period in cattle. The Journal of General Virology, 88, 1363–1373.CrossRefGoogle Scholar
  24. Wells, G. A., Scott, A. C., Johnson, C. T., Gunning, R. F., Hancock, R. D., Jeffrey, M., et al. (1987). A novel progressive spongiform encephalopathy in cattle. Veterinary Record, 121, 419–420.CrossRefGoogle Scholar
  25. Wilesmith, J. W., Ryan, J. B. M., Hueston, W. D., & Hoinville, L. J. (1992). Bovine spongiform encephalopathy: Epidemiological features 1985 to 1990. Veterinary Record, 130, 90–94.CrossRefGoogle Scholar
  26. Will, R. G., Ironside, J. W., Zeidler, M., Cousens, S. N., Estibeiro, K., Alperovitch, A., et al. (1996). A new variant of Creutzfeldt-Jakob disease in the UK. Lancet, 347, 921–925.CrossRefGoogle Scholar
  27. Yamamoto, T., Tsutsui, T., Nishiguchi, A., & Kobayashi, S. (2008). Simulation-based estimation of BSE infection in Japan. Preventive Veterinary Medicine, 84, 135–151.CrossRefGoogle Scholar
  28. Yamamoto, T., Tsutsui, T., Nonaka, T., Kobayashi, S., Nishiguchi, A. & Yamane, I. (2006). A quantitative assessment of the risk of exposure to bovine spongiform encephalopathy via meat-and-bone meal in Japan. Preventive Veterinary Medicine, 75, 221–238.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Epidemiological Research Team, National Institute of Animal HealthTsukuba-shiJapan
  2. 2.Division of Biomedical Food ResearchNational Institute of Health Sciences, Setagaya-kuTokyoJapan

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