Simplifying Complex Dynamic Networks: A Model of Protease Imbalance and COPD Dynamic Dose-Response

Part of the International Series in Operations Research & Management Science book series (ISOR, volume 129)

The risk models in previous chapters have emphasized causal processes described by directed acyclic graphs (Bayesian network models) and by multistage carcinogenic processes in which exposure hastens the net transition rates and increases the net proliferation rates of affected cells. More is required to predict the probable consequences of interventions in feedback-control systems, where changing the levels of controllable inputs can affect not only the specific subprocesses targeted by the interventions, but also the equilibrium levels of other variables throughout the entire interconnected system.


Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Neutrophil Elastase Equilibrium Level Outflow Rate 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Cox AssociatesDenverUSA

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