Primary Nonepithelial Malignancies

  • Yener S. Erozan
  • Ibrahim Ramzy
Part of the Essentials in Cytopathology book series (EICP, volume 6)


Primary lymphomas of lung are rare (less than 1% of lung tumors), and the majority of them are marginal zone B-cell lymphomas of mucosa-associated lymphoid tissues (MALT) type. Diffuse large B-cell lymphomas comprise a small proportion (5–20%) of the primary lung lymphomas. Primary pulmonary Hodgkin lymphoma is very rare. Other lymphomas, Hodgkin and non-Hodgkin types, may also involve lung as part of the systemic disease.


Hodgkin lymphoma, as in other sites, is diagnosed by identifying Reed-Sternberg cells, usually in transbronchial/tracheal fine needle aspirations. On rare occasions, the typical Reed-Sternberg cells can be found in sputum (Fig. 8.1A,B). Immunostains for CD30, CD15, and Fascin confirm the diagnosis (Fig. 8.2). Low grade lymphomas, such as MALT type which are composed mostly of small lymphocytes, are difficult to diagnose in cytologic samples, such as needle aspirations and bronchial brush or wash specimens. The diagnosis of lymphoma can be...


Spindle Cell Hodgkin Lymphoma Synovial Sarcoma Spindle Cell Carcinoma Spindle Cell Sarcoma 
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Suggested Reading

  1. Hummel P, Cangiarella JF, Cohen JM, et al. Transthoracic fine-needle aspiration biopsy of pulmonary spindle cell and mesenchymal lesions: a study of 61cases. Cancer (Cancer Cytopathol) 2001;93:187–198Google Scholar
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  4. Weiss SW, Goldblum JR. Enzinger and Weiss’s Soft Tissue Tumors, ed 5, Philadelphia, PA, Elsevier, 2008Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Johns Hopkins School of MedicineBaltimoreUSA
  2. 2.University of IrvineUSA

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