Primary Epithelial Malignancies

Part of the Essentials in Cytopathology book series (EICP, volume 6)


Carcinoid Tumor Small Cell Carcinoma Adenoid Cystic Carcinoma Merkel Cell Carcinoma Tissue Fragment 

Suggested Reading

  1. Alasio TM, Sun W, Yang GCH. Giant cell carcinoma of the lung impact of diagnosis and review of cytological features. Diagn Cytopathol 2007;35:555–559PubMedCrossRefGoogle Scholar
  2. Al-Haddad M, Wallace MB. EUS-FNA and biomarkers for the staging of non-small cell lung cancer. Endoscopy 2006;38:114–117CrossRefGoogle Scholar
  3. Anderson C, Ludwig ME, O’Donnell M, et al. Fine needle aspiration cytology of pulmonary carcinoid tumors. Acta Cytol 1990;34:505–510PubMedGoogle Scholar
  4. Auger M, Katz AL, Johnston DA. Differentiating cytologic features of bronchioalveolar carcinoma from adenocarcinoma of the lung in fine-needle aspiration: a statistical analysis of 27 cases. Diagn Cytopathol 1997;16:253–257PubMedCrossRefGoogle Scholar
  5. Baba M, Iyoda A, Nomoto Y, et al. Cytological findings of pre-invasive bronchial lesions detected by light-induced fluorescence endoscopy in a lung cancer screening system. Oncol Rep 2007;17:579–583PubMedGoogle Scholar
  6. Beasley MB. Immunohistochemistry of pulmonary and pleural neoplasia. Arch Pathol Lab Med. 2008 Jul;132:1062–1072. ReviewPubMedGoogle Scholar
  7. Bhat N, Bhagat P, Pearlman ES, et al. Transbronchial needle aspiration biopsy in the diagnosis of pulmonary neoplasms. Diagn Cytopathol 1990;6:14–17PubMedCrossRefGoogle Scholar
  8. Cagle PT, Kovach M, Ramzy I. Causes of false results in transthoracic fine needle lung aspirates. Acta Cytol 1993;37:16–20PubMedGoogle Scholar
  9. Dabbs DJ. Diagnostic immunohistochemistry, ed 2. New York, NY, Churchill Livingstone, 2002Google Scholar
  10. Dacic S. EGFR assays in lung cancer. Adv Anat Pathol 2008;15:241–247. ReviewPubMedCrossRefGoogle Scholar
  11. Dacic S. Pulmonary preneoplasia. Arch Pathol Lab Med 2008;132:1073–1078. ReviewPubMedGoogle Scholar
  12. Daneshbod Y, Modjtahedi E, Atefi S, et al. Exfoliative cytologic findings of primary pulmonary adenoid cystic carcinoma. A report of 2 cases with a review of the cytologic features. Acta Cytol 2007;51:558–562PubMedCrossRefGoogle Scholar
  13. Duncan LD, Jacob S, Atkinson S. Fine needle aspiration findings of micropapillary carcinoma in the lung. A case report. Acta Cytol 2007;51:605–608Google Scholar
  14. Erkiliç S, Ozsaraç C, Küllü S. Sputum cytology for the diagnosis of lung cancer: comparison of smear and modified cell block methods. Acta Cytol 2003;47:1023–1027PubMedCrossRefGoogle Scholar
  15. Fekete PS, Cohen C, DeRose PB. Pulmonary spindle cell carcinoid-needle aspiration biopsy, histologic and histochemical findings. Acta Cytol 1990;34:50–56PubMedGoogle Scholar
  16. Franks TJ, Galvin JR. Lung tumors with neuroendocrine morphology: essential radiologic and pathologic features. Arch Pathol Lab Med 2008 Jul;132(7):1055–1061. Review.PubMedGoogle Scholar
  17. Herbst JB, Walts AE. High-grade neuroendocrine carcinoma presenting as an abscess: diagnosis by fine needle aspiration and review of the literature. Diagn Cytopathol 2008;36:670–673PubMedCrossRefGoogle Scholar
  18. Hiroshima K, Abe S, Ebihara Y, et al. Cytological characteristics of pulmonary large cell neuroendocrine carcinoma. Lung Cancer 2005;48:331–337PubMedCrossRefGoogle Scholar
  19. Hiroshima K, Iyoda A, Shida T, et al. Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. Mod Pathol 2006;19:1358–1368PubMedCrossRefGoogle Scholar
  20. Hughes JH, Young NA, Wilber DC, et al. Cytopathology Resource Committee, College of American Pathologists: Fine-needle aspiration of pulmonary hamartoma: a common source of false-positive diagnosis in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Arch Pathol Lab Med 2005;129:19–22PubMedGoogle Scholar
  21. Kakinuma H, Mikami T, Iwabuchi K, et al. Diagnostic findings of bronchial brush cytology for pulmonary large cell neuroendocrine carcinomas: comparison with poorly differentiated adenocarcinomas, squamous cell carcinomas, and small cell carcinomas. Cancer 2003;99:247–254PubMedCrossRefGoogle Scholar
  22. Katz RL, Zaidi TM, Fernandez RL, et al. Automated detection of genetic abnormalities combined with cytology in sputum is a sensitive predictor of lung cancer. Mod Pathol 2008;21:1065CrossRefGoogle Scholar
  23. Kennedy TC, McWilliams A, Edell E, et al. American College of Chest Physicians: Bronchial intraepithelial neoplasia/early central airways lung cancer: ACCP Evidence-based Clinical Practice Guidelines (2nd ed). Chest 2007;132:221S–233SPubMedCrossRefGoogle Scholar
  24. Marek W, Richartz G, Philippou S, et al. Sputum screening for lung cancer in radon exposed uranium miners: a comparison of semi-automated sputum cytometry and conventional cytology. J Physiol Pharmacol 2007;58 Suppl 5(Pt 1):349–361PubMedGoogle Scholar
  25. Marmor S, Koren R, Halpern M, et al. Transthoracic needle biopsy in the diagnosis of large-cell neuroendocrine carcinoma of the lung. Diagn Cytopathol 2005;33:238–243PubMedCrossRefGoogle Scholar
  26. Mathews S, Erozan YS. Pulmonary sequestration – a diagnostic pitfall. A case report. Diagn Cytopathol 1997;16:353–357CrossRefGoogle Scholar
  27. Mullins RK, Thompson SK, Coogan PS, et al. Paranuclear blue inclusions: an aid in the cytopathologic diagnosis of primary and metastatic pulmonary small-cell carcinoma. Diagn Cytopathol 1994;4:332–335CrossRefGoogle Scholar
  28. Naryshkin S, Young NA. Respiratory cytology: a review of non-neoplastic mimics of malignancy. Diagn Cytopathol 1993;9:89–97PubMedCrossRefGoogle Scholar
  29. Nicholson SA, Ryan MR. A review of cytologic findings in neuroendocrine carcinomas including carcinoid tumors with histologic correlations. Cancer Cytopathol 2000;90:148–161CrossRefGoogle Scholar
  30. Policarpio-Nicolas MLC, Wick MR. False-positive interpretations in respiratory cytopathology: exemplary cases and literature review. Diagn Cytopathol 2008;36:13–19PubMedCrossRefGoogle Scholar
  31. Saad RS, Lindner JL, Lin X et al. The diagnostic utility of D2-40 for malignant mesothelioma versus pulmonary carcinoma with pleural involvement. Diagn Cytopathol 2006;34:801–806PubMedCrossRefGoogle Scholar
  32. Saleh HA, Haapaniemi J, Khatib G, et al. Bronchioloalveolar carcinoma. Diagnostic pitfalls and immunocytochemical contribution. Diagn Cytopathol 1998;18:301–306PubMedCrossRefGoogle Scholar
  33. Shibuya K, Fujisawa T, Hoshino H, et al. Fluorescence bronchoscopy in the detection of preinvasive bronchial lesions in patients with sputum cytology suspicious or positive for malignancy. Lung Cancer 2001;32:19–25PubMedCrossRefGoogle Scholar
  34. Silverman JF, Finley JL, Park HK, et al. Fine needle aspiration cytology of bronchioalveolar cell carcinoma of the lung. Acta Cytol 1995;29: 887–894Google Scholar
  35. Thiryayi SA, Rana DN, Perera DM. Bronchial carcinoid tumor: cytologic features on ThinPrep and a diagnostic pitfall in bronchial brushings and washings. Diagn Cytopathol 2008;36:275–276PubMedCrossRefGoogle Scholar
  36. Travis WD, Brambilla E, Muller-Hermelink HK, et al (eds). World Health Organization classification of tumours. Pathology and genetics of tumours of the lung, pleura, thymus and heart. IARC Press, Lyon, 2004Google Scholar
  37. Wang KP, Marsh BR, Summer WR, et al. Transbronchial needle aspiration for diagnosis of lung cancer. Chest 1981;80:48–50PubMedCrossRefGoogle Scholar
  38. Wiatrowska BA, Krol J, Zakowski MF. Large-cell neuroendocrine carcinoma of the lung: proposed criteria for cytologic diagnosis. Diagn Cytopathol 2001;24:58–64PubMedCrossRefGoogle Scholar
  39. Wong PW, Stefanec T, Brown K, et al. Role of fine-needle aspirates of focal lung lesions in patients with hematologic malignancies. Chest 2002;121:527–532PubMedCrossRefGoogle Scholar
  40. Wu M, Szporn AH, Zhang D, et al. Cytology applications of p63 and TTF-1 immunostaining in differential diagnosis of lung cancers. Diagn Cytopathol 2005;33:223–227PubMedCrossRefGoogle Scholar
  41. Yang YJ, Steele CT, Ou XL, et al. Diagnosis of high-grade pulmonary neuroendocrine carcinoma by fine-needle aspiration biopsy: nonsmall-cell or small-cell type? Diagn Cytopathol 2001:25:292–300PubMedCrossRefGoogle Scholar
  42. Zaman SS, vanHoeven KH, Slott S, et al. Distinction between bronchioloalveolar carcinoma and hyperplastic pulmonary proliferations: a cytologic and morphometric analysis. Diagn Cytopathol 1997;16:396–401PubMedCrossRefGoogle Scholar
  43. Zhang H, Liu J, Cagle PT, et al. Distinction of pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma: an immunohistochemical approach. Mod Pathol 2005;18:111–118PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Johns Hopkins School of MedicineBaltimoreUSA
  2. 2.University of IrvineUSA

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