Primary Epithelial Malignancies

  • Yener S. Erozan
  • Ibrahim Ramzy
Part of the Essentials in Cytopathology book series (EICP, volume 6)

Lung cancer is the most common cancer in the world and is the leading cause of cancer deaths in both men and women in the United States. Almost all primary malignant neoplasms of lung (99.0%) are carcinomas. Four types: squamous cell carcinoma, adenocarcinoma, small cell carcinoma, and large cell carcinoma, constitute the majority of tumors. Carcinoid tumors, typical and atypical, comprise a small proportion of lung neoplasms. They belong to the category of neuroendocrine neoplasms which include large cell neuroendocrine carcinoma and small cell carcinoma; but they differ from the latter in regard to association with smoking, prognosis, and some other clinical aspects. Some lung carcinomas may have neuroendocrine differentiation demonstrated by immunohistochemistry without the characteristic microscopic features of neuroendocrine differentiation. Although this could occur in all non-small cell carcinomas, it is most commonly seen in adenocarcinomas. These tumors are reported according...


Carcinoid Tumor Small Cell Carcinoma Adenoid Cystic Carcinoma Merkel Cell Carcinoma Tissue Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Johns Hopkins School of MedicineBaltimoreUSA
  2. 2.University of IrvineUSA

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