Other Nonneoplastic Conditions

  • Yener S. Erozan
  • Ibrahim Ramzy
Part of the Essentials in Cytopathology book series (EICP, volume 6)

Bronchial Asthma

Allergens induce a reaction characterized by hyperplasia of the columnar ciliated and mucinous cells lining the bronchial tree and plugging of small bronchi by inspissated mucin. Cytologic material shows sheets or tightly cohesive three-dimensional fragments of hypersecretory respiratory epithelium with goblet cells and ciliated columnar cells, referred to as “Creola bodies.” Abundant mucus is present in the background, and casts of small bronchi and bronchioles, in the form of Curschmann spirals, are often identified. Increased numbers of eosinophils is a reflection of the allergic nature of the disease. This is associated with the presence of Charcot–Leyden crystals which result from crystallization of the protein in the cytoplasm of eosinophils (Fig. 5.1).


Idiopathic Pulmonary Fibrosis Nuclear Atypia Pulmonary Infarct Altered Immune Reaction Pulmonary Alveolar Proteinosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Suggested Reading

  1. Aisner SC, Gupta PK, Frost JK. Sputum cytology in pulmonary sarcoidosis. Acta Cytol 1997;21:394–398Google Scholar
  2. Dundore PA, Aisner SC, Templeton PA, et al. Nodular pulmonary amyloidosis: diagnosis by fine-needle aspiration cytology and review of the literature. Diagn Cytopathol 1993;9:562–564PubMedCrossRefGoogle Scholar
  3. Hsiu JG, Stitik FP, D’Amato NA, et al. Primary amyloidosis presenting as a unilateral hilar mass: report of a case by fine needle aspiration biopsy. Acta Cytol 1986;30:55–58PubMedGoogle Scholar
  4. Silverman JF, Turner RC, West RL, et al. Bronchoalveolar lavage in the diagnosis of lipoid pneumonia. Diagn Cytopathol 1989;5:3–8PubMedCrossRefGoogle Scholar
  5. Smojver-Jezek S, Peros-Golubicic T, Tekavec-Trkanjec J, et al. Transbronchial fine needle aspiration cytology in the diagnosis of mediastinal/hilar sarcoidosis. Cytopathology 2007;18:3–7PubMedCrossRefGoogle Scholar
  6. Sosolik RC, Gammon RR, Julius CJ, et al. Pulmonary alveolar proteinosis. A report of two cases with diagnostic features in bronchoalveolar lavage specimens. Acta Cytol 1998;42:377–383PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Johns Hopkins School of MedicineBaltimoreUSA
  2. 2.University of IrvineUSA

Personalised recommendations