Other Nonneoplastic Conditions
Part of the Essentials in Cytopathology book series (EICP, volume 6)
Allergens induce a reaction characterized by hyperplasia of the columnar ciliated and mucinous cells lining the bronchial tree and plugging of small bronchi by inspissated mucin. Cytologic material shows sheets or tightly cohesive three-dimensional fragments of hypersecretory respiratory epithelium with goblet cells and ciliated columnar cells, referred to as “Creola bodies.” Abundant mucus is present in the background, and casts of small bronchi and bronchioles, in the form of Curschmann spirals, are often identified. Increased numbers of eosinophils is a reflection of the allergic nature of the disease. This is associated with the presence of Charcot–Leyden crystals which result from crystallization of the protein in the cytoplasm of eosinophils (Fig. 5.1).
KeywordsIdiopathic Pulmonary Fibrosis Nuclear Atypia Pulmonary Infarct Altered Immune Reaction Pulmonary Alveolar Proteinosis
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