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Specimen Collection and Processing

  • Yener S. Erozan
  • Ibrahim Ramzy
Chapter
Part of the Essentials in Cytopathology book series (EICP, volume 6)

Proper collection and processing of cytologic specimens are crucial for an accurate cytopathologic diagnosis. In most instances, failure to establish a definitive diagnosis is caused either by inadequate sampling of the lesion or by suboptimal preparation of the specimen.

Specimen Collection

Pulmonary specimen collection techniques are listed in Table 1.1. The most frequently used techniques in current practice are bronchoscopy and fine needle aspiration (FNA). FNAs (transbronchial or transthoracic) are performed under imaging guidance, i.e., ultrasound (US) or computed tomography (CT). More recently, EUS guided FNA is increasingly used in the diagnosis of mediastinal lesions and the staging of lung cancer. On-site evaluation for adequacy improves the yield of diagnosis in FNA. Selection of the technique is determined by the location of the lesion (Table 1.2) and also the expertise of the physician (e.g., radiologist, pulmonologist) performing the procedure.
Table 1.1

Pulmonary...

Keywords

Fine Needle Aspiration Core Biopsy Hank Balance Salt Solution Cell Block Polypropylene Glycol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Johns Hopkins School of MedicineBaltimoreUSA
  2. 2.University of IrvineUSA

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