Fluorescence Solvent Relaxation in Cationic Membranes

  • Agnieszka Olżyńska
  • Piotr Jurkiewicz
  • Martin Hof
Part of the Reviews in Fluorescence book series (RFLU, volume 2007)


The interest in positively charged lipid membranes stems from biology, where cationic lipids are used for delivery of nucleic acids into host cells to achieve transgene expression or gene regulation – techniques that are essential for genomics and proteomics. Electrostatic interaction of polyanionic DNA or RNA with cationic lipids leads to the formation of the so-called lipoplex, which functions as a transfection vector [1–4]. Complexation with lipids facilitates the cell uptake of genetic material, in particular crossing the hydrophobic barrier of cellular membrane. The efficiency of lipofection is still lower than transfection with viral vectors, but this is the safety and biocompatibility that drew attention to the lipofection in medicine.


Lipid Bilayer Cationic Lipid Liquid Crystalline State Solvent Relaxation Headgroup Region 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Agnieszka Olżyńska
    • 1
  • Piotr Jurkiewicz
    • 1
  • Martin Hof
    • 1
  1. 1.J. Heyrovský Institute of Physical Chemistry of the ASCR182 23 Prague 8Czech Republic

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