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Functional Defects of Dendritic Cells in Cancer

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Dendritic Cells in Cancer

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Abstract

Altered dendritic cell function is one of the most fundamental mechanisms of tumor escape from immune surveillance. Functional characteristics of dendritic cells evolve with their differentiation and are tightly controlled by the cytokine network. Tumors actively interfere with dendritic cell differentiation and their acquisition of functional properties and render them defective. This chapter reviews the data characterizing the effect of tumor on the key functions of dendritic cells, including antigen uptake, antigen presentation, expression of cell surface molecules, motility and cytokine production.

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  1. Division of Hematology and Oncology, Department of Medicine, Vanderbilt University, 2200 Pierce Ave., 648 PRB, Nashville, TN 37232-6838, USA

    Mikhail M. Dikov

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    Dikov, M.M., Chekneva, I.S. (2009). Functional Defects of Dendritic Cells in Cancer. In: Salter, R., Shurin, M. (eds) Dendritic Cells in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-88611-4_4

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