Dendritic Cell Vaccines in Cancer: Obstaclesto Overcome

  • Ezra D. Mirvish
  • Rebecca G. Pomerantz
  • Louis D. Falo
  • Larisa J. Geskin


Significant progress has been made in the development of cancer immunotherapies. However, as advances continue to unravel the complexity of the immune system and processes involved in the induction of antitumor immunity and tolerance, new questions increasingly arise. Various approaches have been undertaken in an effort to induce efficient antitumor immunity. Dendritic cells are the most potent antigen-presenting cells known, and this capacity of dendritic cells has been exploited against various malignancies under different conditions. This chapter reviews various controversies in dendritic cell-based vaccine development, including sources of dendritic cells, their differentiation, maturation and antigen loading, vaccine delivery, as well as effective monitoring of the immune and clinical responses in vivo.


Dendritic Cell Dendritic Cell Maturation Immature Dendritic Cell Dendritic Cell Vaccine Myeloid Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ezra D. Mirvish
  • Rebecca G. Pomerantz
  • Louis D. Falo
  • Larisa J. Geskin
    • 1
  1. 1.Cutaneous Oncology and Photopheresis CenterUniversity of Pittsburgh School of MedicinePittsburghUSA

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