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Dendritic Cells in Cancer: Emergenceof the Discipline

  • Michael R. Shurin
  • Michael T. Lotze
Chapter

Abstract

Immunologic research, following the discovery of dendritic cells radically changed our understanding of the induction, maintenance, and emergence of immune-mediated inflammatory disorders, including malignant diseases. The mechanisms central to the etiology and pathogenesis of many of these chronic inflammatory conditions involve dendritic cells. Identification of dendritic cells in tumors as well as clinical evaluation of dendritic cell vaccines led to the realization that very complex interactions between dendritic cells and other cellular and extracellular components of the tumor microenvironment dictated clinical outcome. Dendritic cells interestingly either induce antitumor immune response or promote a wound repair phenotype including reparative epithelial tumor proliferation, resumption of “barrier function”, promotion of the premetastatic niche, and metastases. The limited success of dendritic cell-based therapies suggests the need for a deeper understanding of immunobiology of these key cells of the immune system as they develop within the complex tumor microenvironment. Reanalyzing and reexamining the accumulated data and concepts in the field, as done in this chapter and the book overall, serve this important goal.

Keywords

Dendritic Cell Antitumor Immunity Antitumor Immune Response Dendritic Cell Vaccine Dendritic Cell Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Clinical ImmunopathologyUniversity of Pittsburgh Medical Center and University of Pittsburgh Cancer InstitutePittsburghUSA

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