Protumorigenic Function of Dendritic Cells

  • Anjli Kukreja


A growing body of evidence suggests a strong role of the tumor microenvironment in shaping up the final outcome of tumor progression. The focus is now on how various stromal components interact with cancer cells to promote tumor growth and metastasis. Infiltration of dendritic cells is a common feature of most human tumors and until recently, these tumor-infiltrating dendritic cells have largely been studied for their immunologic properties. Current studies reveal a more active role of dendritic cells in the microenvironment leading to tumor enhancement, angiogenesis and bone resorption. These observations have tremendous applications for tumor therapy and suggest a need to better understand the ways by which dendritic cells regulate tumor biology in terms of their antigen-presenting as well as tumor-supporting functions including transdifferentiation into other cell types. This review focuses on the protumorigenic effects of dendritic cells in tumor progression that can be targeted to improve cancer therapy.


Vascular Endothelial Growth Factor Dendritic Cell Tumor Microenvironment Mantle Cell Lymphoma Multinucleated Giant Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Section of HematologyYale UniversityNew HavenUSA

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